Inhibition Errors in Schizophrenia: An fMRI/MEG Study

精神分裂症的抑制错误：功能磁共振成像/脑磁图研究

• 批准号: 6946340
• 负责人: Frida Eleonora Polli
• 金额: $ 2.18万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-04 至 2006-08-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6946340
• 关键词: adult human (21+); bioimaging /biomedical imaging; brain electrical activity; brain imaging /visualization /scanning; clinical research; cognition; corpus striatum; functional magnetic resonance imaging; hippocampus; human subject; magnetoencephalography; neural information processing; neural inhibition; neuropsychology; patient oriented research; predoctoral investigator; prefrontal lobe /cortex; saccades; schizophrenia

DESCRIPTION (provided by applicant): Long-term Goals: 1. To advance my knowledge of preserved versus impaired cognitive functions in schizophrenia, and how they relate to the psychiatric manifestations of the disorder. 2. To learn to conduct research in cognitive neuroscience using high resolution spatiotemporal imaging, including rapid presentation, event-related fMRI and MEG. 3. To become proficient in design, implementation and data analysis of combined fMRI/MEG projects. Specific Aims: I. In healthy subjects, to identify the spatiotemporal patterns of activation associated with a) intact inhibition, b) inhibition errors, and c) error processing using rapid-presentation, event-related fMRI and MEG. II. In schizophrenia, to identify the stages at which inhibition is abnormal and error processing is intact with regard to the location, timing, and magnitude of neural activation using rapid-presentation, event-related fMRI and MEG.

描述（由申请人提供）：