Rumination, arousal and cognition in depression: an fMRI/EEG study

抑郁症中的沉思、唤醒和认知：一项功能磁共振成像/脑电图研究

• 批准号: 7744654
• 负责人: Frida Eleonora Polli
• 金额: $ 5.32万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7744654
• 关键词: Agitation; Arousal; Attenuated; Behavioral; Biological Neural Networks; Caliber; Cause of Death; Clinical; Cognition; Cognitive; Data; Disease; Electroencephalography; Episodic memory; Event; Fatigue; Functional Magnetic Resonance Imaging; Functional disorder; High Prevalence; Hyperactive behavior; Impairment; Individual; Length; Link; Major Depressive Disorder; Measures; Mind; Modality; Multimodal Imaging; Neurophysiology - biologic function; Patients; Pattern; Performance; Phase; Psychological Tests; Psychopathology; Psychophysiology; Public Health; Pupil; Questionnaires; Recruitment Activity; Resolution; Rest; Severities; Severity of illness; Sleeplessness; Societies; Symptoms; Testing; Transcranial magnetic stimulation; base; cognitive function; control trial; cost; density; depressed; depression; depressive symptoms; economic cost; improved; indexing; interest; mortality; relating to nervous system; response; sample fixation

DESCRIPTION (provided by applicant): I propose that in depression, excessive rumination and dysregulated arousal serve to undermine general cognitive ability and functioning. I aim to explore this hypothesis at the behavioral and neural level. Rumination is a core feature of depression (Nolen-Hoeksema 2000), and predicts numerous indices of depressive psychopathology (Miranda and Nolen-Hoeksema 2007). Aim 1: Default mode network activation will be associated with rumination, and increased in depression. I propose that rumination, as reflected in hyperactivity of the default mode network, interferes with the functioning of a task-positive network underpinning correctly-performed demanding cognitive activity. Aim 2: During correct trials, default mode network hyperactivity will correlate with attenuated task-positive network activity in depression. I propose that arousal is dysregulated in depression, manifested in clinical symptoms such as diminished interest, fatigue, psychomotor agitation/retardation, and insomnia/hypersomnia, and will result in abnormal psychophysiological and neural responses to arousing events, such as errors on a cognitive task. Aim 3. During error trials, neural and psychophysiological measures of arousal will be increased in depression. Finally, I propose that dysregulated arousal also correlates with attenuated optimal functioning of the taskpositive network. Aim 4. During post-error trials, arousal-based enhancement of the task-positive network will be attenuated in depression. This application would test these hypotheses using a) an attentional task (Eriksen flanker task); b) multimodal imaging, including rapid presentation event-related functional magnetic resonance imaging (er-fMRI) and high density (128 channel) electroencephalography (EEG); c) concurrent psychophysiological indices (pupillometry); and d) measures of symptomatogloy and propensity to ruminate. We propose to recruit 30 patients with major depresive disorder (MOD) and 30 healthy control subjects. With 10-25% lifetime prevalence, high mortality (8th leading cause of death in the US in 1997), and a very high economic cost for society ($44 billion in the US in 1990), major depressive disorder (MDD) is a significant public health problem. We posit that dysregulation of networks involved in rumination, arousal and cognition are fundamental to the pathophysiology of depression. Characterization of this dysfunction could improve new neurotherapeutic treatments, such as repeated transcranial magnetic stimulation (rTMS,) for a disorder with such high individual and societal costs.

描述（由申请人提供）：我认为，在抑郁症中，过度的沉思和失调的唤醒有助于破坏一般的认知能力和功能。我的目标是在行为和神经水平上探索这一假设。沉思是抑郁症的核心特征（Nolen-Hoeksema 2000），并预测了抑郁症精神病理学的许多指标（米兰达和Nolen-Hoeksema 2007）。目的1：默认模式网络激活将与反刍相关，并在抑郁症中增加。我建议，反刍，反映在过度活跃的默认模式网络，干扰的功能的任务积极的网络支持正确执行要求的认知活动。目的2：在正确的试验中，默认模式网络活动过度与抑郁症的任务积极网络活动减弱相关。我认为抑郁症患者的觉醒失调，表现为临床症状，如兴趣减退、疲劳、精神激动/迟缓和失眠/嗜睡，并将导致对唤醒事件的异常心理生理和神经反应，如认知任务的错误。目标3.在错误试验中，抑郁症患者的神经和心理生理唤醒指标会增加。最后，我提出，失调的唤醒也与衰减的最佳功能的taskpositive网络。目标4。在错误后实验中，基于唤醒的任务积极网络的增强在抑郁症中会减弱。本申请将使用以下方法测试这些假设：a）注意力任务（Eriksen flanker任务）; B）多模态成像，包括快速呈现事件相关功能磁共振成像（er-fMRI）和高密度（128通道）脑电图（EEG）; c）并发心理生理学指标（瞳孔测量）;以及d）脑电描记术和反刍倾向的测量。我们计划招募30名重度抑郁症（MOD）患者和30名健康对照者。重度抑郁症（MDD）是一个严重的公共卫生问题，其终生患病率为10-25%，死亡率高（1997年美国第8大死亡原因），社会经济成本非常高（1990年美国为440亿美元）。我们认为，参与反刍，唤醒和认知的网络失调是抑郁症的病理生理学基础。这种功能障碍的表征可以改善新的神经治疗方法，例如重复经颅磁刺激（rTMS），用于治疗具有如此高的个人和社会成本的疾病。