Dissecting the link between Clostridioides difficile, the intestinal microbiota and host factors to determine patient outcome.

剖析艰难梭菌、肠道微生物群和宿主因素之间的联系，以确定患者的治疗结果。

• 批准号: 2397703
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2397703
• 关键词: Dissecting; link; between; Clostridioides; difficile

Clostridioides difficile is the leading cause of nosocomial antibiotic-associated diarrhoea worldwide, yet little is known about colonisation of the intestinal tract and disease relapse. Treatment with antibiotics for an underlying condition alters the intestinal microbiota, which results in susceptibility to colonisation with C. difficile. Current data indicates that 20-30% of patients suffering from C. difficile infection (CDI) relapse within two months post-treatment with increasing probability of relapsing multiple times, indicating the presence of a potential reservoir of C. difficile re-seeding the intestinal tract of susceptible patients. We suggest there are there are distinct community and proteomic signatures linked to C. difficile disease.

艰难梭菌是全世界医院内抗生素相关性腹泻的主要原因，但人们对肠道定植和疾病复发知之甚少。使用抗生素治疗潜在疾病会改变肠道微生物群，从而导致对艰难梭菌定植的敏感性。目前的数据表明，20-30%的艰难梭菌感染（CDI）患者在治疗后两个月内复发，并且多次复发的可能性不断增加，这表明存在潜在的艰难梭菌储存库，在易感患者的肠道中重新播种。我们认为存在与艰难梭菌疾病相关的独特群落和蛋白质组特征。