1,1,1-三氯-2-醇结构不仅是一些重要天然产物的结构单元,也是合成a-氨基酸,a-羟基酸，a-氟化羧酸等的有用前体。但是至今并没有有效的、通用的不对称这类化合物的方法；其通常是通过CBS还原对应的酮而得。Corey-Link反应是反应条件最为温和的制备1,1,1-三氯-2-醇类化合物的方法。它甚至对含有alfa-质子、易烯醇化的醛都能给出良好产率。但目前为止，并没有对反应中关键溶剂DMF的作用的研究报道，也没有催化不对称研究的例子。. 基于已有文献对DMF研究的基础上我们认为三氯甲基负离子会与DMF形成加成物。这样我们设计了一类以Koga胺为母核的催化剂以期能实现不对称催化的Corey-Link反应，同时希望反应过程中形成的氢键能够固定催化剂的构象而增加三氯甲基负离子对甲酰基加成的选择性，并且这样的氢键也能稳定这类加成物。最后该反应将被应用于天然产物的全合成。

Trichloromethyl carbinols are not only an important structural units in natural products, but also synthetic equivalents of alfa-amino acids, alfa-hydroxyacids and alfa-fluorocarboxylic acids. However, there is no general and efficient method of catalytic synthesis of this class of compounds. Currently, they are ususally prepared through CBS-reduction of the corresponding trichloromethyl ketones. Corey-Link reaction is the mildest reaction protocol to prepare trichloromethyl carbinols: trichloroacetic acid and sodium trichloroacetate were added to a solution of aldehyde in DMF at room temperature. The enolizable aldehyde also afforded high yields. However, there is no report on the role of DMF in Corey-Link reaction, and no documented results of catalytic asymmetric synthesis of trichloromethyl carbinols via Corey-Link reaction.. On the basis of the studies in many DMF-mediated reactions, we believe that an adduct of trichloromethyl anion to DMF might be formed during the reaction. Thus, a dual activation catalyst based on Koga amine, bearing a formamide group and a amine group (base) will be prepared. The hydrogen bond was expected to play a pivotal role: fixing the conformation and stabling the adduct of trichloromethyl anion and formamide group. It was anticipated that catalytic asymmetric synthesis of trichloromethyl carbinols via Corey-Link reaction will be realized. Finally the new developed method will be applied in the total synthesis of natural product: Muironolide A.