Sleep, Inflammation & Mental Health in Modern Society: PSYCHONEUROIMMUNE PATHWAYS

睡眠、炎症

• 批准号: 2397707
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2397707
• 关键词: Sleep; Inflammation; Mental; Health; Modern

It is well documented that psychosocial stressors and sleep have a reciprocal relationship and both are identified determinants of mental health. Research to elucidate the biological mechanisms underlying these associations are essential to reducing socioeconomic disparities in health. Compelling hypotheses have been put forward to explain these relationships, including the hypothalamic-pituitary stress system, a hallmark in the stress response, and inflammation. However, psychoneuroimmune pathways, have been proposed as a more proximal mechanism, with changes seen to cellular, molecular and epigenetic forms of plasticity. The stressors of modern society are postulated to provoke this downward trajectory of effects. Stress poses risk to adaptive sleep routines, and these disruptions to sleep cycles have neuroimmune implications, with downstream associations to psychological distress and psychopathology on a continuum of severity. It is therefore submitted that maladaptive sleep impacts the causal pathway between stress and mental ill-health by modulating neuroimmune processes. The significance of the differences in outcome symptomology and severity is unknown, but this heterogeneity in psychological presentation suggests a gene-environmental interaction.

有充分证据表明，心理社会压力源和睡眠具有相互关系，并且两者都被确定为心理健康的决定因素。阐明这些关联背后的生物学机制的研究对于减少健康方面的社会经济差距至关重要。人们提出了令人信服的假设来解释这些关系，包括下丘脑-垂体应激系统（应激反应的标志）和炎症。然而，心理神经免疫途径被认为是一种更近端的机制，其可塑性的细胞、分子和表观遗传形式发生了变化。人们认为现代社会的压力源会引发这种下降的效应。压力会给适应性睡眠习惯带来风险，而这些睡眠周期的干扰会产生神经免疫影响，并在严重程度上与心理困扰和精神病理学产生下游关联。因此，有人认为，适应不良的睡眠通过调节神经免疫过程来影响压力和精神疾病之间的因果关系。结果症状和严重程度差异的意义尚不清楚，但心理表现的这种异质性表明基因与环境的相互作用。