Evaluating the link between the GPR91 receptor and renin in the pathogenesis of diabetic retinopathy

评估 GPR91 受体和肾素在糖尿病视网膜病变发病机制中的联系

• 批准号: nhmrc : 1002235
• 负责人: A/Pr Janos Peti-Peterdi
• 金额: $ 32.46万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/evaluating-link-gpr91-diabetic-retinopathy/108789
• 关键词: Evaluating; link; between; GPR91; receptor

Diabetic retinopathy is the leading cause of blindness in people of working age. A hormonal system called renin-angiotensin is implicated in the development of diabetic retinopathy, and new evidence indicates that its blockade improves aspects of the disease. This project will examine if succinate/GPR91 mediates the over production of renin and represents an additional target for the treatment of diabetic retinopathy.

糖尿病视网膜病变是导致工作年龄人群失明的主要原因。一种称为肾素-血管紧张素的激素系统与糖尿病视网膜病变的发展有关，新的证据表明，阻断它可以改善疾病的某些方面。该项目将研究琥珀酸/GPR 91是否介导肾素的过度产生，并代表治疗糖尿病视网膜病变的另一个靶点。