Cell engineering to explore safe and effective new approaches for nervous system regenerative medicine

组织工程为神经系统损伤的修复提供了一个令人兴奋的未来选择。这种方法需要稳定的治疗细胞来源，可以安全地植入以支持和指导神经元再生。永生化细胞系是有用的工具，因为它们保留了原代细胞的特征，并且是同质细胞的无限来源。该项目的目的是利用离体基因疗法开发安全稳定的人类细胞系来改造多能干细胞，然后利用数学建模和组织工程工具将这些细胞与生物材料结合起来，产生新一代的活体人工组织。

Tissue engineering offers an exciting future option for repair of nervous system injuries. Thisapproach requires a stable source of therapeutic cells that can be implanted safely to supportand direct neuronal regeneration. Immortalized cell lines are useful tools as they retaincharacteristics of primary cells and are an unlimited source of homogeneous cells. The aim ofthis project is to develop safe stable human cell lines using ex vivo gene therapy to engineerpluripotent stem cells, and then combine these cells with biomaterials using mathematicalmodelling and tissue engineering tools, to generate a new generation of living artificialtissues.