The role of Calcium channels in bursting and plasticity

描述（由申请人提供）：本研究拟探讨电压激活的Ca2+通道在下托神经元的棘波放电模式中的作用，以及棘波放电模式是否会影响可塑性的诱导。具体来说，我提出了一系列的药理学实验，以辨别各种高电压激活的Ca2+通道的Ca2+尾电流驱动器海马下托神经元爆裂的相对作用。将使用分子技术确认经鉴定的Ca2+通道的存在。最后，我将探讨尖峰放电模式的差异对LTP诱导的影响。

DESCRIPTION (provided by applicant): This study proposes to explore the role of voltage activated Ca2+ channels in spike-firing mode of subicular neurons and whether spike-firing mode can influence the induction of plasticity. Specifically, I propose a series of pharmacological experiments to discern the relative roles of the various high voltage activated Ca2+ channels in the Ca2+-tail current that drives bursting in subicular neurons of the hippocampus. The presence of the pharmacologically identified Ca2+ channels will be confirmed using molecular techniques. Finally, I will explore the effect of differences in spike-firing mode on the induction of LTP.