The role of Calcium channels in bursting and plasticity

钙通道在破裂和可塑性中的作用

• 批准号: 6784083
• 负责人: TIM M JARSKY
• 金额: $ 3.38万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-12-06 至 2005-12-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6784083
• 关键词: role; Calcium; channels; bursting; plasticity

DESCRIPTION (provided by applicant): This study proposes to explore the role of voltage activated Ca2+ channels in spike-firing mode of subicular neurons and whether spike-firing mode can influence the induction of plasticity. Specifically, I propose a series of pharmacological experiments to discern the relative roles of the various high voltage activated Ca2+ channels in the Ca2+-tail current that drives bursting in subicular neurons of the hippocampus. The presence of the pharmacologically identified Ca2+ channels will be confirmed using molecular techniques. Finally, I will explore the effect of differences in spike-firing mode on the induction of LTP.

描述(申请人提供)：本研究旨在探讨电压激活的钙通道在下丘脑神经元放电模式中的作用，以及放电模式是否会影响可塑性的诱导。具体地说，我提出了一系列药理学实验，以辨别各种高电压激活的钙通道在驱动海马束下神经元爆发的钙尾流中的相对作用。药物鉴定的钙通道的存在将通过分子技术得到证实。最后，我将探讨不同的放电模式对长时程增强诱导的影响。