The role of Calcium channels in bursting and plasticity

钙通道在破裂和可塑性中的作用

• 批准号: 6585247
• 负责人: TIM M JARSKY
• 金额: $ 4.11万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-12-06 至 2005-12-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6585247
• 关键词: calcium channel; calcium channel blockers; electrophysiology; hippocampus; laboratory rat; long term potentiation; neural conduction; neural plasticity; neurophysiology; polymerase chain reaction; predoctoral investigator; voltage /patch clamp; voltage gated channel

DESCRIPTION (provided by applicant): This study proposes to explore the role of voltage activated Ca2+ channels in spike-firing mode of subicular neurons and whether spike-firing mode can influence the induction of plasticity. Specifically, I propose a series of pharmacological experiments to discern the relative roles of the various high voltage activated Ca2+ channels in the Ca2+-tail current that drives bursting in subicular neurons of the hippocampus. The presence of the pharmacologically identified Ca2+ channels will be confirmed using molecular techniques. Finally, I will explore the effect of differences in spike-firing mode on the induction of LTP.

描述（由申请人提供）：本研究拟探讨电压激活的Ca2+通道在下托神经元的棘波放电模式中的作用，以及棘波放电模式是否会影响可塑性的诱导。具体来说，我提出了一系列的药理学实验，以辨别各种高电压激活的Ca2+通道的Ca2+尾电流驱动器海马下托神经元爆裂的相对作用。将使用分子技术确认经鉴定的Ca2+通道的存在。最后，我将探讨尖峰放电模式的差异对LTP诱导的影响。