The role of Calcium channels in bursting and plasticity

18. 奖学金培训和职业目标以下目标旨在为我在研究和教学机构的教职岗位做准备。1. 在5年内完成学位。2. 学习多种实验技术。3. 培养科学的阅读和写作技能。4. 在完成学位之前获得博士后职位。5. 在离开实验室前公布结果。6. 在会议上展示结果。赞助商19。姓名和学位(S)纳尔逊·斯普鲁斯顿_博士20。职位/职级副教授研究方向/领域活跃树突整合在突触塑性中的作用[j]； / / / /; 22。本研究拟探讨电压激活的Ca2*通道在丘下神经元的spike-firing模式中的作用，以及spike-firing模式是否会影响可塑性的诱导。具体来说，我提出了一系列药理学实验，以揭示各种高压激活Ca2 *通道在驱动海马潜神经元破裂的Ca2+- tl电流中的相对作用。药理学上确定的ca2¿通道的存在将使用分子技术进行确认。最后，我将探讨不同的spike-firing mode对LTP诱导的影响。小灵通416 - 1(启12/98)表单页面2 BB cc个人NRSA应用程序目录 ======================================== 节结束 ===========================================

18. GOALS FOR FELLOWSHIP TRAINING AND CAREER The following goals are designed with the intent of preparing me for a faculty position at a research and teaching institution. 1. Complete degree in less than 5 years. 2. Learn multiple experimental techniques. 3. Develop scientific reading and writing skills. 4. Secure a post-doctoral position prior to completion of degree. 5. Publish results prior to leaving lab. 6. Present results at a conference. SPONSOR 19. NAME AND DEGREE(S) Nelson Spruston_ PhD 20. POSITION/RANK Associate Professor 21. RESEARCH INTERESTS/AREAS Acitve dendritic integration i role of active processes in sTnaptic plastici ,ty / / / / II 22. DESCRIPTION (Do not exceed space provided) This study proposes to explore the role of voltage activated Ca2*channels in spike-firing mode of subicular neurons and whether spike-firing mode can influence the induction of plasticity. Specifically, I propose a series of pharmacological experiments to discem the relative roles of the various high voltage activated Ca 2* channels in the Ca2+-tafl current that drives bursting in subicular neurons of the hippocampus. The presence of the pharmacologically identified Ca 2¿channels will be confirmed using molecular techniques. Finally, I will explore the effect of differences in spike-firing mode on the induction of LTP. PHS 416-1 (Rev. 12/98) Form Page 2 BB cc Individual NRSA Application Table of Contents ========================================Section End===========================================