The role of Calcium channels in bursting and plasticity

钙通道在破裂和可塑性中的作用

• 批准号: 6837074
• 负责人: TIM M JARSKY
• 金额: $ 3.38万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-12-06 至 2005-12-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6837074
• 关键词: role; Calcium; channels; bursting; plasticity

18. GOALS FOR FELLOWSHIP TRAINING AND CAREER The following goals are designed with the intent of preparing me for a faculty position at a research and teaching institution. 1. Complete degree in less than 5 years. 2. Learn multiple experimental techniques. 3. Develop scientific reading and writing skills. 4. Secure a post-doctoral position prior to completion of degree. 5. Publish results prior to leaving lab. 6. Present results at a conference. SPONSOR 19. NAME AND DEGREE(S) Nelson Spruston_ PhD 20. POSITION/RANK Associate Professor 21. RESEARCH INTERESTS/AREAS Acitve dendritic integration i role of active processes in sTnaptic plastici ,ty / / / / II 22. DESCRIPTION (Do not exceed space provided) This study proposes to explore the role of voltage activated Ca2*channels in spike-firing mode of subicular neurons and whether spike-firing mode can influence the induction of plasticity. Specifically, I propose a series of pharmacological experiments to discem the relative roles of the various high voltage activated Ca 2* channels in the Ca2+-tafl current that drives bursting in subicular neurons of the hippocampus. The presence of the pharmacologically identified Ca 2¿channels will be confirmed using molecular techniques. Finally, I will explore the effect of differences in spike-firing mode on the induction of LTP. PHS 416-1 (Rev. 12/98) Form Page 2 BB cc Individual NRSA Application Table of Contents ========================================Section End===========================================

18.奖学金培训和职业目标以下目标是为了让我为在研究和教学机构担任教职做好准备而设计的。1.在不到5年的时间内完成学位。2.学习多种实验技术。3.培养科学的阅读和写作能力。4.在完成学位之前获得博士后职位。5.在离开实验室之前发布结果。6.在会议上展示成果。19. honeymoon姓名和学位纳尔逊·斯普鲁斯顿_博士20。21.第21章.研究兴趣/领域活性树突状细胞整合i的作用，在突触质膜的活性过程，TY /II 22。本研究拟探讨电压激活的Ca ~（2+）通道在海马下托神经元锋电位放电模式中的作用以及锋电位放电模式是否影响可塑性的诱导。具体地说，我提出了一系列的药理学实验，以探讨各种高电压激活的Ca 2+通道在驱动海马下托神经元爆发的Ca 2 +-tafl电流中的相对作用。将使用分子技术确认已鉴定的Ca 2+通道的存在。最后，我将探讨尖峰放电模式的差异对LTP诱导的影响。PHS 416-1（12/98修订版）表格第2页BB cc个人NRSA申请目录==