The role of Calcium channels in bursting and plasticity

18.奖学金培训和职业目标以下目标是为我在一家研究和教学机构担任教职做准备。1.在5年内完成学位。2.学习多种实验技术。3.培养科学的阅读和写作能力。4.在完成学位之前获得一个博士后职位。5.在离开实验室之前公布结果。6.在一次会议上展示成果。19.赞助商姓名及学位(S)斯普鲁斯顿博士20.职位/职级副教授研究兴趣/领域活跃的树突整合I活跃过程在转化体中的作用，ty///II 22。说明(不超过所提供的篇幅)本研究旨在探讨电压激活的钙通道在下丘脑神经元放电模式中的作用，以及放电模式是否会影响可塑性的诱导。具体地说，我提出了一系列药理学实验，以揭示各种高电压激活的钙通道在推动海马束下神经元爆发的钙-tafl电流中的相对作用。药理鉴定的钙通道的存在将通过分子技术得到证实。最后，我将探讨不同的放电模式对长时程增强诱导的影响。PHS 416-1(12/98版)表第2页bb cc个人非RSA申请目录========================================Section End===========================================

18. GOALS FOR FELLOWSHIP TRAINING AND CAREER The following goals are designed with the intent of preparing me for a faculty position at a research and teaching institution. 1. Complete degree in less than 5 years. 2. Learn multiple experimental techniques. 3. Develop scientific reading and writing skills. 4. Secure a post-doctoral position prior to completion of degree. 5. Publish results prior to leaving lab. 6. Present results at a conference. SPONSOR 19. NAME AND DEGREE(S) Nelson Spruston_ PhD 20. POSITION/RANK Associate Professor 21. RESEARCH INTERESTS/AREAS Acitve dendritic integration i role of active processes in sTnaptic plastici ,ty / / / / II 22. DESCRIPTION (Do not exceed space provided) This study proposes to explore the role of voltage activated Ca2*channels in spike-firing mode of subicular neurons and whether spike-firing mode can influence the induction of plasticity. Specifically, I propose a series of pharmacological experiments to discem the relative roles of the various high voltage activated Ca 2* channels in the Ca2+-tafl current that drives bursting in subicular neurons of the hippocampus. The presence of the pharmacologically identified Ca 2¿channels will be confirmed using molecular techniques. Finally, I will explore the effect of differences in spike-firing mode on the induction of LTP. PHS 416-1 (Rev. 12/98) Form Page 2 BB cc Individual NRSA Application Table of Contents ========================================Section End===========================================