Addressing antimicrobial resistance with peptides: novel sactipeptides from genome mining

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Antimicrobial resistance is a huge threat to global public health and new compounds areurgently needed to address this escalating crisis. Bacterial natural products are a vastreservoir of such compounds. One class of peptidic bacterial natural products with promisingactivities and selectivities are the sactipeptides. Several sactipeptides have been predicted inknown bacterial species using genome mining,[1] though only six have been isolated andcharacterised to date. The aim of this project is therefore to identify novel sactipeptides frombacteria, characterise their structure and activity, and investigate the production ofanalogues using the sactipeptide biosynthetic machinery.