MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT

描述(由申请人提供)： 本申请概述了一项广泛的培训和研究计划，该计划将贯穿该奖项的五年。培训包括三个主要的学习目标：(1)熟悉青少年药物滥用的有效门诊治疗；(2)发展进行随机临床试验的知识和经验；(3)学习和利用最先进的统计方法来评估治疗结果。培训计划详细说明了应聘者用来实现这些目标的具体目标。 申请书中描述的研究计划将调整和评估多系统疗法(MST)，这是一种以家庭和家庭为基础的强化治疗计划，针对即将面临外出安置风险的行为和情感障碍的青少年，用于治疗患有肥皂水的青少年，并在门诊环境中内化精神健康诊断。研究计划将分四个阶段进行。在第一阶段，申请者将修改MST治疗手册、监督手册、质量保证方案和治疗师培训方案，以用于门诊环境中治疗双重诊断的青年。在第二阶段，申请者将在社区青少年门诊诊所的10名青少年中试行经调整的手册、质量保证系统和治疗师培训方案。根据接受治疗的青年和家庭成员、诊所管理员、治疗师和MST专家监督员的反馈，手册和质量保证体系将在第三阶段进行完善和修订。最后，第四阶段将包括一项试点研究，对40名被诊断为双重诊断的青年随机分配治疗条件，其中20人接受MST门诊治疗，20人接受普通门诊服务。对治疗前、入院后6个月、入院后12个月进行多方法、多来源的综合评估，以评价治疗效果。 《研究计划》包括三个具体目标： 具体目标1 本研究的主要目的是适应和测试多系统疗法在门诊环境中用于治疗被诊断为药物使用障碍和共病内化障碍的青少年。 具体目标2 除了改善症状，目前的研究旨在测试门诊MST在与青少年成功发展相关的其他领域改善青年功能的有效性。 具体目标3 拟议研究的最终目标是提供比社区中通常提供的服务更容易为消费者接受的服务。

DESCRIPTION (provided by applicant): The present application outlines an extensive training and research program that extends throughout the five years of the award. The training plain includes three overarching learning objectives: (1) Gain familiarity with validated outpatient treatments for adolescent substance abuse; (2) Develop knowledge of and experience with conducting randomized clinical trials; and (3) Learn and utilize state-of-the-art statistical methods for evaluating treatment outcomes. The Training Plan details the specific goals the candidate will use to meet these objectives. The Research Plan described in the application will adapt and evaluate Multisystemic Therapy (MST), an intensive family- and home-based treatment program for behaviorally and emotionally disordered youth at imminent risk for out-of-home placement, for use in treating youth with comorbid SUDs and internalizing mental health diagnoses in an outpatient setting. The Research Plan will be conducted in four phases. In Phase I the applicant will adapt the MST treatment manual, supervision manual, quality assurance protocol, and therapist training protocol for use in outpatient settings to treat dually diagnosed youth. In Phase II, the applicant will pilot test the adapted manuals, quality assurance system, and therapist training protocol with 10 adolescents in a community-based youth outpatient clinic. Based on feedback from youth and family members receiving the treatment, clinic administrators, therapists, and expert MST supervisors, the manuals and quality assurance system will be refined and revised during Phase III. Finally, Phase IV will include a pilot study of 40 dually diagnosed youth, randomly assigned to treatment conditions, with 20 receiving Outpatient MST and 20 receiving usual outpatient services. Comprehensive multimethod, multisource assessments will be conducted pretreatment, 6 months post entry, and 12 months post entry to evaluate treatment effectiveness. The Research Plan includes three specific aims: Specific Aim 1 The primary aim of the present research is to adapt and test Multisystemic Therapy for use in outpatient settings to treat youth diagnosed with a substance use disorder and comorbid internalizing disorder. Specific Aim 2 Besides improved symptomatology, the current research aims to test the effectiveness of Outpatient MST to improve youth functioning in other domains pertinent to successful adolescent development. Specific Aim 3 The final aim of the proposed research is to provide services that are more acceptable to consumers than are usual services provided in the community.