Enabling Technologies for Combinatorial Chemistry

该资助申请描述了一项研究计划，旨在开发用于有机合成和分子多样性构建的新合成技术。具体地说，拟议的研究旨在探索合成的潜在的O2-和IBX试剂，并开发合成技术的基础上的光诱导化学的o-取代苯甲醛和α-磺化羰基化合物的反应性，无论是在溶液和固相。最后，对这些新技术在全合成和组合化学中的应用进行了展望。 设计和合成的化合物将根据各种生物测定进行筛选，以进行铅鉴定，作为促进肿瘤学和其他疾病领域的化学生物学研究和药物发现计划的一种手段。

This grant application describes a research program directed at the development of new synthetic technologies for organic synthesis and molecular diversity construction. Specifically, the proposed research aims to explore the synthetic potential of the DMP and IBX reagents and to develop synthetic technologies based on the photo-induced chemistry of o- substituted benzaldehydes and the reactivity of alpha-sulfonated carbonyl compounds, both in solution and on solid phase. Applications of the developed technologies to total synthesis and combinatorial chemistry are also proposed. The designed and synthesized compounds will be screened against a variety of biological assays for lead identification as a means to facilitate chemical biology studies and drug discovery programs in oncology and other disease areas.