Synthesis of Marine Neurotoxins
海洋神经毒素的合成
基本信息
- 批准号:7821404
- 负责人:
- 金额:$ 44.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-07-01 至 2012-04-30
- 项目状态:已结题
- 来源:
- 关键词:AlkenesAntibodiesBiologicalBiological TestingBiologyC-glycosideCarbonChemicalsConsumptionDetectionDevelopmentEnvironmental HealthHumanInvestigationKnowledgeLaboratoriesMarinesMeasurementMeasuresMedicineMethodsNeurotoxinsOceansPharmacologic SubstancePoisoningProcessPyransRadioimmunoassayReactionResearchResolutionSchemeSeafoodSideStructureTechnologyWorkbasechemical synthesisdrug discoveryimprovedmaitotoxinmeetingsnovelpreventprogramsstereochemistry
项目摘要
DESCRIPTION (provided by applicant): This proposal describes a research program directed towards resolving a stereochemical controversy over the structure of the marine neurotoxin maitotoxin through chemical synthesis, the total synthesis of a truncated version of maitotoxin lacking the side chains, the total synthesis of maitotoxin, and the development of antibodies of suitable maitotoxin-like structures for analytical and biological studies. The escalating challenges of this chemical synthesis program will be met by a convergent strategy involving methods developed in this and other laboratories. Featured in the synthetic plans are olefin metathesis- based carbon-carbon bond forming reactions, novel asymmetric processes and ring closures. Synthetic truncated maitotoxin-like molecules will be tested for biological activity and developed antibodies will become available for the detection and measurement of maitotoxin and further biological studies. The proposed program is also expected to yield significant new synthetic strategies and technologies for broader applications in the drug discovery and development process, particularly for the synthesis of small enantiomerically pure building blocks suitable for pharmaceutical research. Overall the significance of the proposed work lies in improving and assuring environmental health, detecting and measuring marine neurotoxins and cleaning the oceans, as well as to prevent human poisoning through seafood consumption. The project is also expected to significantly advance our knowledge in chemical synthesis, chemical biology, and medicine
描述(由申请人提供):本提案描述了一项研究计划,旨在通过化学合成解决海洋神经毒素美托毒素结构的立体化学争议,缺乏侧链的美托毒素截短版本的全合成,美托毒素的全合成,以及开发用于分析和生物学研究的合适的美托毒素样结构的抗体。这个化学合成计划的不断升级的挑战将通过一个融合的战略来满足,包括在这个实验室和其他实验室开发的方法。在合成计划中的特色是基于烯烃复分解的碳-碳键形成反应,新颖的不对称方法和环闭合。合成的截短的maitotoxin样分子将被测试的生物活性和开发的抗体将成为可用于检测和测量maitotoxin和进一步的生物学研究。该计划还有望产生重要的新合成策略和技术,用于药物发现和开发过程中更广泛的应用,特别是用于合成适合药物研究的小对映体纯构建单元。总的来说,拟议工作的重要性在于改善和确保环境健康,检测和测量海洋神经毒素,清洁海洋,以及防止人类因食用海产品而中毒。该项目还有望大大提高我们在化学合成,化学生物学和医学方面的知识
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
K. C. NICOLAOU其他文献
K. C. NICOLAOU的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('K. C. NICOLAOU', 18)}}的其他基金
TOTAL SYNTHESIS OF KINAMYCINS AND LOMAIVITICINS
运动霉素和洛马霉素的全合成
- 批准号:
7215159 - 财政年份:2006
- 资助金额:
$ 44.73万 - 项目类别:
相似海外基金
Development of blood-brain barrier-crossing antibodies utilizing the biological features of glucose transporters
利用葡萄糖转运蛋白的生物学特性开发血脑屏障跨越抗体
- 批准号:
21K18268 - 财政年份:2021
- 资助金额:
$ 44.73万 - 项目类别:
Grant-in-Aid for Challenging Research (Pioneering)
Development of Minimally Invasive MR Imaging Method for biological materials Using Carbon-13 Labeled Antibodies
使用碳 13 标记抗体开发生物材料微创 MR 成像方法
- 批准号:
21K07568 - 财政年份:2021
- 资助金额:
$ 44.73万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Sex as a Biological Variable Supplement - Neutralizing human-derived single-chain antibodies against SARS-CoV-2
性别作为生物变量补充剂 - 中和人源性单链抗 SARS-CoV-2 抗体
- 批准号:
424696 - 财政年份:2020
- 资助金额:
$ 44.73万 - 项目类别:
Operating Grants
Modulation of cardiac cell signaling with synthetic antibodies, and their characterization as potential therapeutics and probes for basic biological research
用合成抗体调节心脏细胞信号传导,及其作为基础生物学研究潜在疗法和探针的表征
- 批准号:
366643 - 财政年份:2016
- 资助金额:
$ 44.73万 - 项目类别:
Operating Grants
Biological Significance of Protamine/Heparin Antibodies
鱼精蛋白/肝素抗体的生物学意义
- 批准号:
8868489 - 财政年份:2015
- 资助金额:
$ 44.73万 - 项目类别:
Biological Significance of Protamine/Heparin Antibodies
鱼精蛋白/肝素抗体的生物学意义
- 批准号:
9136851 - 财政年份:2015
- 资助金额:
$ 44.73万 - 项目类别:
Biological Significance of Protamine/Heparin Antibodies
鱼精蛋白/肝素抗体的生物学意义
- 批准号:
9294104 - 财政年份:2015
- 资助金额:
$ 44.73万 - 项目类别:
Understanding biological ignificance of histone modifications by epigenetic manipulation using multifunctional antibodies
使用多功能抗体通过表观遗传操作了解组蛋白修饰的生物学意义
- 批准号:
26291071 - 财政年份:2014
- 资助金额:
$ 44.73万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Biological Significance of Protatmine/Heparin Antibodies
鱼精蛋白/肝素抗体的生物学意义
- 批准号:
8592644 - 财政年份:2013
- 资助金额:
$ 44.73万 - 项目类别:
Analysis of biological function and efficacy of anti EGFR antibodies isolated from screening of human antibody phage display library specific to human renal cell carcinoma
人肾细胞癌特异性抗体噬菌体展示库筛选分离抗EGFR抗体的生物学功能和功效分析
- 批准号:
20591870 - 财政年份:2008
- 资助金额:
$ 44.73万 - 项目类别:
Grant-in-Aid for Scientific Research (C)