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Deep tissue hyper-spectral imaging using multi-mode fibre-based flexible micro-endoscopy

使用基于多模光纤的柔性微内窥镜进行深部组织高光谱成像

基本信息

批准号：
2402859
负责人：
金额：
--
依托单位：
UNIVERSITY OF EXETER
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2402859
关键词：
Deep tissue hyper spectral imaging

项目摘要

The aim of the project is to develop a new form of ultra-thin multimode fibre based endoscope. Multimode fibres (MMFs) are able to transfer optical signals in the most information dense way: with many (1000's) independent channels able to propagate through an optical fibre only several tens of microns in diameter. Combined, these channels can transfer images from one end of the fibre to the other. However, as the phase velocity of each channel is different, then images projected onto one end of the fibre become scrambled into an apparently random speckle pattern upon arrival at the other end of the fibre. MMFs can be calibrated - enabling images to be unscrambled, however this calibration changes wherever the fibre bends, rendering imaging through flexible MMFs an open challenge. This project will build on recent work of the Structured Light Group, led by Assoc. Prof. David Phillips at Exeter, to develop a new way to calibrate and image through flexible multimode fibres while they are able to freely move (see Shuhui Li, Simon AR Horsley, Tomas Tyc, Tomas Cizmar, and David B. Phillips. "Guide-star assisted imaging through multimode optical fibres". ArXiv preprint arXiv:2005.06445 (2020)). This will push forward MMF based imaging technology, and during the project we will explore a wide range of applications including biomedical micro-endoscopy in conjunction with Prof Nick Stone at the University of Exeter.

该项目的目的是开发一种新形式的超薄多模光纤内窥镜。多模光纤（MMF）能够以最密集的方式传输光信号：许多（1000个）独立的通道能够通过直径仅为几十微米的光纤传播。结合起来，这些通道可以将图像从光纤的一端传输到另一端。然而，由于每个通道的相速度不同，因此投影到光纤一端的图像在到达光纤另一端时会被扰乱成明显随机的散斑图案。MMF可以被校准-使图像能够被解扰，然而，无论光纤弯曲到哪里，这种校准都会发生变化，通过灵活的MMF进行成像是一个开放的挑战。该项目将建立在由埃克塞特的副教授大卫菲利普斯领导的结构光小组的最新工作基础上，以开发一种新的方法，在柔性多模光纤能够自由移动时通过柔性多模光纤进行校准和成像（参见Shuhui Li、Simon AR霍斯利、Tomas Tyc、Tomas Cizmar和大卫B。菲利普斯。“通过多模光纤进行导星辅助成像”。ArXiv预印本arXiv：2005.06445（2020））。这将推动基于MMF的成像技术的发展，在该项目中，我们将与埃克塞特大学的Nick Stone教授一起探索广泛的应用，包括生物医学显微内窥镜。