Chronic Kidney Disease with Benign Prostatic Hyperplasia

描述（由申请人提供）：良性前列腺增生（BPH）和慢性肾脏病（CKD）都是老年男性常见的疾病。之前研究这两种疾病之间的关联的研究是在干预时的3 PH患者的病例系列，通常被急性尿潴留混淆。BPH及其尿路感染（UTI）并发症可能是CKD发生的危险因素。本研究将使用一项基于社区的前瞻性纵向队列研究的数据，该研究对2311名男性进行了13年以上的BPH并发症随访。使用线性混合效应回归模型和逻辑回归模型，评估基线BPH替代指标和/或UTI病史与CKD发生之间的关系。基线BPH替代测量是症状评分、峰值尿流率、残余尿量和前列腺大小。CKD的发展将通过血清肌酐的两年纵向变化进行评估。将从病历中提取已知的CKD风险因素，如糖尿病和高血压，并作为潜在混杂因素进行调整。根据初步数据，预计BPH替代指标与CKD之间存在显著相关性。这项研究将阐明是否有必要对BPH进行早期评估和干预以预防CKD。

DESCRIPTION (provided by applicant): Benign Prostatic Hyperplasia (BPH) and Chronic Kidney Disease (CKD) are both common medical conditions in aging men. Prior studies looking at the association between these two diseases have been case series of 3PH patients at the time of intervention, often confounded by acute urinary retention. BPH and its urinary tract infection (UTI) complication may be under-appreciated risk factors for the development of CKD. This study will use data from a community-based prospective longitudinal cohort study of 2311 men followed for complications of BPH over 13 years. Using both a linear mixed effects regression model and a logistic regression model, the relationship between a baseline BPH surrogate measure and/or UTI history with the development of CKD will be assessed. Baseline BPH surrogate measures are a symptom score, peak urinary flow rate, residual urine volume, and prostate size. Development of CKD will be assessed through biennial longitudinal changes in serum creatinine. Known risk factors for CKD such as diabetes mellitus and hypertension will be abstracted from the medical record and adjusted for as potential confounders. Based on preliminary data, a significant association between BPH surrogate measures and CKD is expected. This study will clarify whether earlier assessment and intervention in BPH is warranted to prevent CKD.