Comparison of kidney function measurement methods in the community

社区肾功能测量方法比较

基本信息

批准号：
8139916
负责人：
ANDREW David RULE
金额：
$ 13.77万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-01 至 2012-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8139916
关键词：
Address Adult Affect Age Albuminuria American Appointment Arterial Disorder Attention Award Biometry Cardiovascular Diseases Centers for Disease Control and Prevention (U.S.)Cessation of life Chronic Kidney Failure Classification Clinic Clinical Research Collection Communities Creatinine Creatinine clearance measurement Cross-Sectional Studies Data Development Diabetes Mellitus Dialysis procedure Diet Modification Doctor of Medicine Early Diagnosis Early treatment Environment Epidemiology Equation Excision General Population Glomerular Filtration Rate Gold Grant Hypertension Individual Individual Differences Inflammation Intake Intervention Iothalamate Joints Kidney Kidney Diseases Kidney Failure Knowledge Laboratories Lead Longitudinal Studies Master&apos s Degree Measurement Measures Medicine Mentors Mentorship Metabolic Methods Muscle Proteins Nephrology Patients Peer Review Persons Population Positioning Attribute Prevalence Prevention strategy Race Renal function Research Research Personnel Resources Risk Risk Factors Sampling Serum Societies Staging Study of serum Surrogate Markers Testing Training Transplantation Tubular formation United States Urine Validation Work base cardiovascular disorder risk cardiovascular risk factor clinical practice cohort community setting coronary artery calcification disorder prevention disorder risk genetic epidemiology improved muscle form post gamma-globulins prevent professor programs sex symposium treatment strategy wasting

项目摘要

DESCRIPTION (provided by applicant): Project Summary: The candidate is a nephrologist starting a staff position at the Mayo Clinic on July 1st, 2006. During the past 4 years as a nephrology trainee, the candidate obtained a Master's degree in Clinical Research, first-authored 10 peer-reviewed articles, and received institutional (T32) and individual (F32) National Research Awards. His expertise in the epidemiology of chronic kidney disease and in kidney function methods has gained national attention. He was a grant reviewer for the Centers for Disease Control and Prevention and will moderate a symposium at the American Society of Nephrology Renal Week (2006). The environment will consist of Mayo Clinic - Rochester, where he will have a joint appointment in Nephrology and Epidemiology. His sponsor, Stephen Turner, M.D., Professor of Medicine, will provide him with access to data and train him to be an independent investigator. His mentorship team will also include two Professors of Epidemiology, an Associate Professor of Biostatistics, and the Co-director of the Renal Function Laboratory where 5500 'gold-standard' kidney function measurements are performed annually. The project will compare kidney function measurements between a gold standard method (iothalamate clearance) and more convenient, but potentially less accurate methods, used in clinical practice and in most studies (serum creatinine, cystatin C, estimating equations, and creatinine clearance). The unique feature of this project will be to compare these kidney function methods in community-based samples (mentor's cohort and candidate's cohort). The effect of the kidney function measurement method on coronary artery calcification and risk factor associations with chronic kidney disease will be determined. Relevence: In the United States, 8 million adults have moderate-to-severe reductions in kidney function and are at risk for costly morbid interventions (dialysis or transplantation) and cardiovascular disease. Validation of kidney function methods is needed to identify chronic kidney disease at an earlier stage, characterize its risk factors, and develop new treatment strategies.

描述（由申请人提供）：项目摘要：候选人是一名肾脏科医生，于2006年7月1日在梅奥诊所开始工作。在过去的4年中，作为肾脏病学员，候选人获得了临床研究的硕士学位，首次撰写了10篇同行评审的文章，并接受了机构（T32）和个人研究Awards。他在慢性肾脏疾病和肾功能方法的流行病学方面的专业知识引起了全国关注。他曾是疾病控制和预防中心的赠款审查员，并将在美国肾脏病肾脏周学会（2006）举行一次研讨会。环境将包括梅奥诊所 - 罗切斯特（Rochester），在那里他将在肾脏病和流行病学中联合任命。他的赞助商斯蒂芬·特纳（Stephen Turner），医学教授，将为他提供数据访问权限，并训练他成为独立的调查员。他的指导团队还将包括两位流行病学教授，生物统计学副教授，以及肾功能实验室的联合导演，其中每年进行5500'金标准'肾功能测量。该项目将比较黄金标准方法（Iothamate清除率）与更方便但准确的方法之间的肾脏功能测量，该方法在临床实践和大多数研究中使用（血清肌酐，伴半胱氨酸蛋白酶C，估计方程和肌酐清除率）。该项目的独特功能将是比较基于社区的样本（导师的队列和候选人的同类）中的这些肾脏功能方法。将确定肾功能测量方法对冠状动脉钙化和与慢性肾脏疾病的危险因素关联的影响。相关性：在美国，有800万成年人的肾功能中度降低，并且有昂贵的病态干预措施（透析或移植）和心血管疾病的风险。需要对肾功能方法进行验证，以便在更早的阶段鉴定慢性肾脏疾病，表征其危险因素并制定新的治疗策略。