Rayleigh optical activity: a new spectroscopic technique for chiral samples.

瑞利光学活性：一种用于手性样品的新光谱技术。

• 批准号: 2403835
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2403835
• 关键词: Rayleigh; optical; activity; new; spectroscopic

Rayleigh scattering is the elastic collision of a photon with an atom or molecule; a well-known phenomenon, largely responsible for the blue colour and polarisation of light from the sky. It was predicted some fifty years ago that chiral molecules should respond differently to left- and right-handed circular polarisations of light in this context; a phenomenon now referred to as Rayleigh optical activity. Surprisingly, the experimental observation of Rayleigh optical has not yet been reported for small chiral molecules, in spite of potential applications ranging from the robust assignment of absolute configurations to the rapid monitoring of chiral crystal growth in the next generation of pharmaceutical manufacturing techniques.The aim of the PhD is to develop Rayleigh optical activity as a new spectroscopic technique for chiral samples, by completing the following objectives: (i) extend the existing theory of Rayleigh optical activity; (ii) help design and build a dedicated Rayleigh optical activity spectrometer in the laboratory; (iii) report, for the first time, experimental observations of Rayleigh optical activity for small chiral molecules and (iv) explore potential applications of Rayleigh optical activity. This is in interdisciplinary project that involves not only physics but also chemistry and even biology.

瑞利散射是光子与原子或分子的弹性碰撞;这是一种众所周知的现象，主要负责天空中的蓝色和偏振光。大约50年前就有人预测，手性分子对左右手圆偏振的光的反应应该不同;这种现象现在被称为瑞利光学活性。令人惊讶的是，瑞利光学的实验观察尚未报道小手性分子，尽管潜在的应用范围从绝对构型的鲁棒分配到下一代药物制造技术中手性晶体生长的快速监测。博士的目的是发展瑞利光学活性作为手性样品的新光谱技术，通过完成以下目标：（i）扩展现有的瑞利旋光理论;（ii）帮助设计和建立一个专用的瑞利旋光光谱仪在实验室中;（iii）报告，第一次，实验观察小手性分子的瑞利旋光和（iv）探索瑞利旋光的潜在应用。这是一个跨学科的项目，不仅涉及物理学，还涉及化学甚至生物学。