New iridium-based catalysis methods for C-C, C-N, and C-O bond formation

用于 C-C、C-N 和 C-O 键形成的新型铱基催化方法

• 批准号: 2403802
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2403802
• 关键词: New; iridium; based; catalysis; methods

This collaboration between GSK and the University of Strathclyde is based on an overarching and sustained relationship that has successfully opened new pathways towards research growth and two-directional knowledge exchange. Professor Kerr holds expertise in the area of catalysis and organic synthesis, and has a proven track record in developing methods that are of particular use within the pharmaceutical industry. Specifically, Kerr has developed a growing range of iridium(I) catalysts, which have emerged to become some of the most active species in the area of labelling chemistry and now show promise in their ability to perform C-C, C-N, and C-O bond-forming reactions. GSK's complementary expertise in identifying relevant pharmaceutical targets and desirable molecular architectures for application of the emerging new methods will result in a fruitful research endeavour.As part of the overall programme of work, computationally-driven methods will be used to deliver enhanced understanding of catalyst design and mechanism of action, as well as expansion of emerging reaction scope. The main EPSRC research areas addressed are Catalysis, Chemical Reaction Dynamics and Mechanism, and Synthetic Organic Chemistry.

葛兰素史克与斯特拉斯克莱德大学的合作建立在一种全面而持久的合作关系的基础上，这种合作已经成功地为研究增长和双向知识交流开辟了新的途径。Kerr教授在催化和有机合成领域拥有专业知识，并在开发制药行业特别使用的方法方面拥有良好的记录。具体来说，Kerr已经开发了越来越多的铱(I)催化剂，这些催化剂已经成为标记化学领域最活跃的物种之一，现在它们在进行C-C、C-N和C-O键形成反应方面表现出了希望。GSK在确定相关药物靶点和应用新兴方法的理想分子结构方面的互补专业知识将导致卓有成效的研究努力。作为整个工作计划的一部分，计算驱动的方法将用于提高对催化剂设计和作用机制的理解，以及扩大新出现的反应范围。EPSRC的主要研究领域是催化、化学反应动力学和机理以及合成有机化学。