Mechanism of Opioid Action in the Amygdala

阿片类药物在杏仁核中的作用机制

• 批准号: 6790086
• 负责人: THOMAS F FINNEGAN
• 金额: $ 2.63万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6790086
• 关键词: amygdala; analgesia; analgesics; confocal scanning microscopy; immunocytochemistry; laboratory rat; neural transmission; neuroanatomy; neuropharmacology; neurophysiology; opiate alkaloid; opioid receptor; pain; pharmacokinetics; posttranslational modifications; predoctoral investigator; protein localization; voltage /patch clamp

DESCRIPTION (provided by applicant): The sensation of pain is important for the survival of an organism. In humans, persistent pain can often have debilitating consequences leading to both financial and emotional destruction. Opioid-based drugs represent the most commonly prescribed medication for the treatment of pain. The reason for the popularity of opioids is based on their superior efficacy compared to other compounds. However, it is not fully known why opioids have such a powerful antinociceptive effect. Previous research has suggested that opioids may work through inhibition of ascending circuitry that transmits pain into the brain as well as activation of endogenous descending antinociceptive circuitry. The precise identity of the endogenous circuitry involved in either the transmission or inhibition of pain is not known. Previous studies indicate that the amygdala has a role in not only receiving nociceptive information, but also directly activating the descending antinociceptive circuity. The proposed experiments will examine how mu opioid receptor activation in one nucleus of the amygdala (basolateral) can effect nociceptive input and result in antinociceptive output in another amygdaloid nucleus (central). This information is important for understanding the mechanisms of opioid analgesic action.

描述（由申请人提供）： 疼痛的感觉对于生物的生存很重要。在人类中，持续的痛苦通常会带来令人衰弱的后果，从而导致经济和情感破坏。基于阿片类药物的药物是治疗疼痛治疗的最常见的药物。与其他化合物相比，阿片类药物受欢迎的原因是基于它们的卓越功效。但是，尚不完全清楚阿片类药物具有如此强大的抗伤害感受效应。先前的研究表明，阿片类药物可以通过抑制上升电路来发挥作用，从而将疼痛传播到大脑以及内源性降低的抗伤害感受感电路。尚不清楚与疼痛传播或抑制有关的内源性电路的精确身份。先前的研究表明，杏仁核不仅在接收伤害性信息中发挥作用，而且还直接激活了降低的抗伤害感受感应。提出的实验将检查杏仁核（基底外侧）中一个核中的阿片类受体激活如何影响伤害感受的输入，并在另一个杏仁核核（中心）中导致抗伤害感受感染的输出。该信息对于理解阿片类镇痛作用的机制很重要。