课题基金 / 基金详情

The effects of strain on vocal fold fibroblasts

The effects of strain on vocal fold fibroblasts
压力对声带成纤维细胞的影响
批准号:
6791032
负责人:
Ryan Comfort Branski
金额:
$2.57万
依托单位国家:
美国
项目类别:
财政年份:
2004
资助国家:
美国
项目状态:
已结题
起止时间:
2004-01-01 至 2005-12-31

项目摘要

项目成果

Ryan Comfort Branski的其他基金

相似基金

相关文献

中文摘要
翻译
描述(申请人提供):目前的资金申请提出了一系列实验,这些实验将定量描述细胞对炎症的反应,并进一步尝试在体外模型中量化循环拉伸应变的影响。培养的声带成纤维细胞将暴露于IL-1β,这种方法已被证明在体外可以在不同类型的细胞中诱导无数的促炎作用,包括刺激环氧合酶-2(COX-2)和一氧化氮(NO),以及抑制蛋白多糖的产生。然后,成纤维细胞将受到循环拉伸应变(CTS),模拟(大致)体外声带振荡。据推测,CTS将作为许多IL-1β依赖的促炎作用的拮抗剂。这一发现在许多其他类型的细胞中得到了证实。目前的研究希望提供数据,表明声带振荡作为一种有效的抗炎剂的作用,以及具有长期的组织重塑意义。此外,它还试图结合赞助商目前的NIH投资回报率提供体外数据。
英文摘要
DESCRIPTION (provided by applicant): The current request for funding proposes a series of experiments which will quantitatively describe the cellular response to inflammation and, further, attempt to quantify the effects of cyclic tensile strain in an in vitro model. Fibroblasts cultured from the vocal folds will be exposed to IL-1beta, a method which has been shown to elicit a myriad of pro-inflammatory actions in various cell types in vitro including the stimulation of cyclo-oxygenase-2 (COX-2) and nitric oxide (NO), as well as the inhibition of proteoglycan production. Fibroblasts will then be subjected to cyclic tensile strain (CTS), simulating (roughly) in vitro vocal fold oscillation. It is hypothesized that CTS will act as an antagonist to many of the IL-1beta-dependent proinflammatory actions. This finding has been confirmed in numerous other cell types. The current investigation hopes to provide data suggesting a role for vocal fold oscillations as a potent anti-inflammatory agent as well as having long-term tissue remodeling implications. Furthermore, it seeks to provide in vitro data in conjunction with the Sponsor's current NIH ROI.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Molecular mechanisms underlying optimal glucocorticoid therapy for vocal fold disease
Midcareer Investigator Award in Patient-Oriented Research for Dr. Ryan Branski
Midcareer Investigator Award in Patient-Oriented Research for Dr. Ryan Branski
Midcareer Investigator Award in Patient-Oriented Research for Dr. Ryan Branski
国内基金
海外基金
探讨青光眼小梁滤过泡原位重建术及其诱导Decorin/TGF-β影响青光眼滤过通道瘢痕再形成的机制
  • 批准号:
    2024JJ7015
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
  • 依托单位:
香烟烟雾通过Decorin-PAI-1-p53/p16调控肺泡成纤维细胞衰老在肺气肿的作用及干预研究
  • 批准号:
    82300047
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    30万元
  • 批准年份:
    2023
  • 负责人:
    胡蔚萍
  • 依托单位:
Decorin通过负调控c-Met介导的PI3K/AKT/mTOR自噬通路影响瘢痕疙瘩发生发展的机制研究