Inflammation and Fibrosis of the Vocal Folds

声带炎症和纤维化

• 批准号: 8209045
• 负责人: Ryan Comfort Branski
• 金额: $ 16.36万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-09 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8209045
• 关键词: Address; Agonist; Animals; Anti-Inflammatory Agents; Anti-inflammatory; Autocrine Communication; Beds; Bilateral; Biochemical Process; Cell Line; Cells; Cicatrix; Complex; Coxibs; Cyclic AMP Receptors; Data; Dinoprostone; Dose; Dysphonia; Fetus; Fibroblasts; Fibrosis; Healed; Human; Inflammation; Inflammatory; Inflammatory Response; Injury; Interleukins; Investigation; Laboratories; Lamina Propria; Larynx; Lesion; Literature; Measures; Mediating; Modeling; Molecular; Morbidity - disease rate; Nature; Nuclear Translocation; Outcome; Paracrine Communication; Pathway interactions; Patients; Phase; Phenotype; Principal Investigator; Production; Rattus; Reporting; Role; Severities; Signal Pathway; Signal Transduction; Structure; Techniques; Time; Tissues; Transcriptional Regulation; Transforming Growth Factors; Up-Regulation; Wound Healing; autocrine; base; clinical application; cyclooxygenase 2; cytokine; healing; injured; injury and repair; insight; novel; patient population; programs; public health relevance; regenerative; repaired; response; vocal cord; wound

项目成果

Prostaglandin (PG)E2 exhibits antifibrotic activity in vocal fold fibroblasts.

前列腺素 (PG)E2 在声带成纤维细胞中表现出抗纤维化活性。

• DOI: 10.1002/lary.21795
• 发表时间: 2011
• 期刊: The Laryngoscope
• 作者: Zhou,Hang;Felsen,Diane;Sandulache,VladC;Amin,MilanR;Kraus,DennisH;Branski,RyanC
• 通讯作者: Branski,RyanC

Glucocorticoids regulate extracellular matrix metabolism in human vocal fold fibroblasts.

• DOI: 10.1002/lary.21920
• 发表时间: 2011-09
• 期刊: LARYNGOSCOPE
• 影响因子: 2.6
• 作者: Zhou, Hang;Sivasankar, Mahalakshmi;Kraus, Dennis H.;Sandulache, Vlad C.;Amin, Milan;Branski, Ryan C.
• 通讯作者: Branski, Ryan C.