Optimal RNA-based therapeutics for vocal fold injury and fibrosis
针对声带损伤和纤维化的最佳 RNA 疗法
基本信息
- 批准号:8762049
- 负责人:
- 金额:$ 42.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-06-19 至 2019-05-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAffectAmericanBiologicalBiomechanicsCell ProliferationCellsChronic Obstructive Airway DiseaseCicatrixClinicClinicalClinical TreatmentCollagenComplexDataDepositionDevelopmentDiffuseDirect CostsDiseaseDistantEnvironmentEtiologyExtracellular MatrixFibroblastsFibrosisFinancial costGelGene SilencingGoalsHealedHumanIn VitroIncidenceIncomeInjection of therapeutic agentInjuryInterventionInvestigationLamina PropriaLesionLipidsLongevityMaintenanceMediator of activation proteinMental DepressionMessenger RNAMetabolismModelingNoduleOccupationalOperative Surgical ProceduresOrganOryctolagus cuniculusPathway interactionsPatientsPharmaceutical PreparationsPhenotypePhonationPliabilityPopulationProcessProteinsRNAReagentResearch PersonnelRoleSignal TransductionSignaling ProteinSmall Interfering RNASocial FunctioningSourceStenosisTechniquesTestingTherapeuticTherapeutic EffectTissuesToxic effectTranscriptional RegulationTransfectionTransforming Growth FactorsTreatment ProtocolsUp-RegulationVoiceVoice DisordersWorkWound Healingbasebody systemcytotoxicityexperiencehealinghuman MADH3 proteinimprovedin vivoinjuredinnovationinsightinterestmigrationnanoparticlenovelpublic health relevanceregenerativerepairedresponseresponse to injurystemtherapeutic targettissue repairvocal cordvocalis muscle
项目摘要
DESCRIPTION (provided by applicant): The universality of fibrosis as an underlying etiology for many voice disorders stems from the reparative response to injury. To date, treatments have been largely unsatisfactory. Acknowledging that healing is complex, we seek to expand our recent findings elucidating one regulatory mechanism underlying repair in the vocal folds. Specifically, we seek increased insight into the transforming growth factor (TGF)-¿ signaling cascade. Our preliminary data suggest that targeting this pathway, not TGF-¿ directly, but rather upstream, to be optimal. Smad3, an upstream cytoplasmic signaling protein provides an ideal target for the use of RNA- based therapeutics, specifically small interfering ribonucleic acid (siRNA). However, delivery of siRNA in vivo is complicated by the inherent proteolytic environment. We hypothesize that lipid nanoparticle delivery will address these issues, delivering optimal drug concentrations with reduced toxicity. This investigation is germane; cumulative estimates regarding the incidence of voice disorders across the lifespan are not known, but are hypothesized to be higher than the 3-9% of the population figure that is often cited. This innovative approach has potential to evolve to the clinic across multiple organ systems.
描述(由申请人提供):纤维化作为许多嗓音疾病的潜在病因的普遍性源于对损伤的修复反应。到目前为止,治疗在很大程度上不令人满意。认识到愈合是复杂的,我们寻求扩大我们最近的研究结果阐明一个监管机制修复声带。具体来说,我们寻求更多的洞察转化生长因子(TGF)-信号级联。我们的初步数据表明,靶向这一途径,而不是TGF-β直接,而是上游,是最佳的。Smad 3是一种上游细胞质信号传导蛋白,为使用基于RNA的治疗剂,特别是小干扰核糖核酸(siRNA)提供了理想的靶标。然而,siRNA在体内的递送由于固有的蛋白水解环境而变得复杂。我们假设脂质纳米粒递送将解决这些问题,提供最佳的药物浓度,降低毒性。这项调查是密切相关的;关于整个生命周期中嗓音障碍发生率的累积估计尚不清楚,但假设高于经常引用的人口数字的3-9%。这种创新的方法有可能发展到多器官系统的临床。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Ryan Comfort Branski其他文献
Ryan Comfort Branski的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Ryan Comfort Branski', 18)}}的其他基金
Molecular mechanisms underlying optimal glucocorticoid therapy for vocal fold disease
声带疾病最佳糖皮质激素治疗的分子机制
- 批准号:
10647027 - 财政年份:2023
- 资助金额:
$ 42.1万 - 项目类别:
Midcareer Investigator Award in Patient-Oriented Research for Dr. Ryan Branski
Ryan Branski 博士荣获以患者为导向的研究中的职业生涯中期研究员奖
- 批准号:
10363720 - 财政年份:2021
- 资助金额:
$ 42.1万 - 项目类别:
Midcareer Investigator Award in Patient-Oriented Research for Dr. Ryan Branski
Ryan Branski 博士荣获以患者为导向的研究中的职业生涯中期研究员奖
- 批准号:
10189292 - 财政年份:2021
- 资助金额:
$ 42.1万 - 项目类别:
Midcareer Investigator Award in Patient-Oriented Research for Dr. Ryan Branski
Ryan Branski 博士荣获以患者为导向的研究中的职业生涯中期研究员奖
- 批准号:
10593155 - 财政年份:2021
- 资助金额:
$ 42.1万 - 项目类别:
Multiple mechanisms underlying GR-mediated therapies for fibroplasia of the vocal folds
GR 介导的声带纤维增生治疗的多种机制
- 批准号:
9763596 - 财政年份:2018
- 资助金额:
$ 42.1万 - 项目类别:
Multiple mechanisms underlying GR-mediated therapies for fibroplasia of the vocal folds
GR 介导的声带纤维增生治疗的多种机制
- 批准号:
10224822 - 财政年份:2018
- 资助金额:
$ 42.1万 - 项目类别:
Multiple mechanisms underlying GR-mediated therapies for fibroplasia of the vocal folds
GR 介导的声带纤维增生治疗的多种机制
- 批准号:
10454139 - 财政年份:2018
- 资助金额:
$ 42.1万 - 项目类别:
Optimal RNA-based therapeutics for vocal fold injury and fibrosis
针对声带损伤和纤维化的最佳 RNA 疗法
- 批准号:
9274959 - 财政年份:2014
- 资助金额:
$ 42.1万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 42.1万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 42.1万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 42.1万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 42.1万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 42.1万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 42.1万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 42.1万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 42.1万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 42.1万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 42.1万 - 项目类别:
Research Grant