Primate Model of Drug Abuse: Gender and Hormonal Effects

药物滥用的灵长类动物模型：性别和激素影响

• 批准号: 6791919
• 负责人: MEGAN E ROTH
• 金额: $ 4.3万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6791919
• 关键词: Macaca mulatta; behavior test; behavioral /social science research tag; biological models; cocaine; drug abuse; estrogen inhibitor; estrogens; gender difference; hormone regulation /control mechanism; inhalation drug abuse; menstrual cycle; methamphetamine; oral administration; phencyclidine; postdoctoral investigator; progesterone; psychopharmacology; reinforcer; self medication; smoking; substance abuse related behavior; tamoxifen

DESCRIPTION (provided by applicant): This proposal was designed to examine the effects of gender and menstrual cycle phase on oral and smoked drug self-administration in rhesus monkeys. A goal of the proposed experiments is to extend findings indicating gender and hormonal influences on drug abuse from rodent studies to nonhuman primates using experimental conditions similar to those that elucidate effects of these factors in rodents. Progressive ratio (PR) schedules and a behavioral economic analysis of demand will be used to evaluate the effects of gender and menstrual cycle phase on oral phencyclidine (PCP) and cocaine self-administration. The effects of gender on the escalation of cocaine intake will be examined using a differential access procedure that allows animals short- (1-hr) or long- (6-hr) access to drug self-administration. Following the differential access procedure, gender and menstrual phase differences in the reinforcing effectiveness of cocaine will be assessed using a PR schedule. A PR schedule and demand curve analysis will also be used to determine the relative reinforcing effectiveness of smoked cocaine and methamphetamine in males vs. females and during specific phases of the menstrual cycle.

描述（由申请人提供）： 该提案旨在研究性别和月经周期阶段对恒河猴口服和吸烟药物自我给药的影响。拟议的实验的一个目标是扩大调查结果表明，性别和激素对药物滥用的影响，从啮齿类动物的研究，非人灵长类动物使用的实验条件类似，阐明这些因素在啮齿类动物的影响。将使用渐进比例（PR）时间表和需求的行为经济学分析来评估性别和月经周期阶段对口服苯环己哌啶（PCP）和可卡因自我给药的影响。将使用允许动物短时间（1小时）或长时间（6小时）自我给药的差异化进入程序检查性别对可卡因摄入量递增的影响。在差异化使用程序之后，将使用PR时间表评估可卡因强化有效性的性别和月经期差异。还将使用PR时间表和需求曲线分析来确定男性与女性以及月经周期特定阶段吸食可卡因和甲基苯丙胺的相对强化效果。