Primate Model of Drug Abuse: Gender and Hormonal Effects
Primate Model of Drug Abuse: Gender and Hormonal Effects
批准号:
6791919
负责人:
MEGAN E ROTH
金额:
$4.3万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
未结题
起止时间:
2005-03-30 至
关键词:
Macaca mulattabehavior testbehavioral /social science research tagbiological modelscocainedrug abuseestrogen inhibitorestrogensgender differencehormone regulation /control mechanisminhalation drug abusemenstrual cyclemethamphetamineoral administrationphencyclidinepostdoctoral investigatorprogesteronepsychopharmacologyreinforcerself medicationsmokingsubstance abuse related behaviortamoxifen
中文摘要
描述(由申请人提供):
英文摘要
DESCRIPTION (provided by applicant):
This proposal was designed to examine the effects of gender and menstrual cycle phase on oral and smoked drug self-administration in rhesus monkeys. A goal of the proposed experiments is to extend findings indicating gender and hormonal influences on drug abuse from rodent studies to nonhuman primates using experimental conditions similar to those that elucidate effects of these factors in rodents. Progressive ratio (PR) schedules and a behavioral economic analysis of demand will be used to evaluate the effects of gender and menstrual cycle phase on oral phencyclidine (PCP) and cocaine self-administration. The effects of gender on the escalation of cocaine intake will be examined using a differential access procedure that allows animals short- (1-hr) or long- (6-hr) access to drug self-administration. Following the differential access procedure, gender and menstrual phase differences in the reinforcing effectiveness of cocaine will be assessed using a PR schedule. A PR schedule and demand curve analysis will also be used to determine the relative reinforcing effectiveness of smoked cocaine and methamphetamine in males vs. females and during specific phases of the menstrual cycle.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Effects of Sex and Estrogen on Drug Self-Administration
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批准号:6515883
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项目类别:
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资助金额:$0.95万
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财政年份:2002
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负责人:MEGAN E ROTH
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依托单位:
Effects of Sex and Estrogen on Drug Self-Administration
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批准号:6340035
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项目类别:
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资助金额:$2.5万
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财政年份:2001
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负责人:MEGAN E ROTH
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依托单位:
海外基金