Primate Model of Drug Abuse: Gender and Hormonal Effects

描述(由申请人提供)： 这项建议旨在研究性别和月经周期阶段对恒河猴口服和烟熏药物自我给药的影响。拟议中的实验的一个目标是将表明性别和荷尔蒙对药物滥用的影响的发现从啮齿动物研究扩展到非人类灵长类动物，使用类似于阐明这些因素对啮齿动物影响的实验条件。将使用累进比率(PR)时间表和需求的行为经济学分析来评估性别和月经周期阶段对口服苯环利定(PCP)和可卡因自我给药的影响。将使用一种允许动物短期(1小时)或长时间(6小时)获得药物自我给药的差别获取程序来审查性别对可卡因摄入量增加的影响。在差别获取程序之后，将使用公关计划评估可卡因增强有效性方面的性别和月经阶段差异。公关时间表和需求曲线分析也将用于确定吸烟可卡因和甲基苯丙胺在男性与女性之间以及在月经周期的特定阶段的相对增强效果。

DESCRIPTION (provided by applicant): This proposal was designed to examine the effects of gender and menstrual cycle phase on oral and smoked drug self-administration in rhesus monkeys. A goal of the proposed experiments is to extend findings indicating gender and hormonal influences on drug abuse from rodent studies to nonhuman primates using experimental conditions similar to those that elucidate effects of these factors in rodents. Progressive ratio (PR) schedules and a behavioral economic analysis of demand will be used to evaluate the effects of gender and menstrual cycle phase on oral phencyclidine (PCP) and cocaine self-administration. The effects of gender on the escalation of cocaine intake will be examined using a differential access procedure that allows animals short- (1-hr) or long- (6-hr) access to drug self-administration. Following the differential access procedure, gender and menstrual phase differences in the reinforcing effectiveness of cocaine will be assessed using a PR schedule. A PR schedule and demand curve analysis will also be used to determine the relative reinforcing effectiveness of smoked cocaine and methamphetamine in males vs. females and during specific phases of the menstrual cycle.