Effects of Sex and Estrogen on Drug Self-Administration
性别和雌激素对药物自我给药的影响
基本信息
- 批准号:6340035
- 负责人:
- 金额:$ 2.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-05-01 至
- 项目状态:未结题
- 来源:
- 关键词:3,4 methylenedioxymethamphetamine albino rat behavioral /social science research tag behavioral habituation /sensitization cocaine dosage drug addiction estrogens female gender difference heroin hormone regulation /control mechanism hormone therapy intravenous administration laboratory rat male methamphetamine ovariectomy psychological reinforcement psychopharmacology self medication tamoxifen
项目摘要
DESCRIPTION: (provided by applicant)
This proposal was designed to examine the effects of sex and estrogen on the
self-administration of intravenously (i.v.) delivered drugs in rats. Four
animal models will be used to investigate acquisition, maintenance,
regulation/dysregulation, and reinstatement of drug self-administration. The
effects of sex and estrogen on the acquisition of heroin, methamphetamine and
d, 1-3, 4-methylenedioxymethamphetamine (MDMA) self-administration will be
examined using an autoshaping procedure. A progressive ratio (PR) schedule of
reinforcement and a behavioral economic analysis of demand will be used to
evaluate the effects of sex and estrogen on the maintenance of cocaine and
heroin self-administration. Breakpoint (BP) measures obtained on a PR schedule,
along with slopes and P-max values obtained from demand curves will be used to
evaluate the reinforcing efficacy of several doses of cocaine and heroin.
Differential access to cocaine self-administration will be used to investigate
the effect of sex on the regulation/dysregulation of cocaine intake.
Dose-response curves for cocaine will be obtained to examine group differences
in shifts in the dose-response curves. The effect of estrogen on the
reinstatement of cocaine self-administration will be examined using a priming
model of drug reinstatement in which lever pressing for drug is extinguished by
replacing cocaine infusions with saline infusions. Reinstatement of responding
is then tested by administering a priming injection of cocaine.
描述:(由申请人提供)
该提案旨在研究性和雌激素对
大鼠自行静脉注射药物。四
动物模型将用于研究获取、维护、
调节/失调,以及恢复药物自我给药。这
性和雌激素对海洛因、甲基苯丙胺和甲基苯丙胺获取的影响
d, 1-3, 4-亚甲二氧基甲基苯丙胺 (MDMA) 自行给药
使用自动成形程序进行检查。渐进比率 (PR) 时间表
强化和需求行为经济分析将用于
评估性别和雌激素对维持可卡因和
海洛因自我给药。根据 PR 计划获得的断点 (BP) 测量值,
以及从需求曲线获得的斜率和 P-max 值将用于
评估几种剂量的可卡因和海洛因的增强功效。
可卡因自我给药的差异化途径将用于调查
性别对可卡因摄入调节/失调的影响。
将获得可卡因的剂量反应曲线以检查组间差异
剂量反应曲线的变化。雌激素对身体的影响
将使用启动检查来检查可卡因自我给药的恢复情况
药物恢复模型,其中按下药物的杠杆被熄灭
用盐水输注代替可卡因输注。恢复响应
然后通过注射可卡因来进行测试。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MEGAN E ROTH其他文献
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{{ truncateString('MEGAN E ROTH', 18)}}的其他基金
Primate Model of Drug Abuse: Gender and Hormonal Effects
药物滥用的灵长类动物模型:性别和激素影响
- 批准号:
6791919 - 财政年份:2005
- 资助金额:
$ 2.5万 - 项目类别:
Effects of Sex and Estrogen on Drug Self-Administration
性别和雌激素对药物自我给药的影响
- 批准号:
6515883 - 财政年份:2002
- 资助金额:
$ 2.5万 - 项目类别:
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