Effects of Sex and Estrogen on Drug Self-Administration

性别和雌激素对药物自我给药的影响

基本信息

  • 批准号:
    6340035
  • 负责人:
  • 金额:
    $ 2.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-05-01 至
  • 项目状态:
    未结题

项目摘要

DESCRIPTION: (provided by applicant) This proposal was designed to examine the effects of sex and estrogen on the self-administration of intravenously (i.v.) delivered drugs in rats. Four animal models will be used to investigate acquisition, maintenance, regulation/dysregulation, and reinstatement of drug self-administration. The effects of sex and estrogen on the acquisition of heroin, methamphetamine and d, 1-3, 4-methylenedioxymethamphetamine (MDMA) self-administration will be examined using an autoshaping procedure. A progressive ratio (PR) schedule of reinforcement and a behavioral economic analysis of demand will be used to evaluate the effects of sex and estrogen on the maintenance of cocaine and heroin self-administration. Breakpoint (BP) measures obtained on a PR schedule, along with slopes and P-max values obtained from demand curves will be used to evaluate the reinforcing efficacy of several doses of cocaine and heroin. Differential access to cocaine self-administration will be used to investigate the effect of sex on the regulation/dysregulation of cocaine intake. Dose-response curves for cocaine will be obtained to examine group differences in shifts in the dose-response curves. The effect of estrogen on the reinstatement of cocaine self-administration will be examined using a priming model of drug reinstatement in which lever pressing for drug is extinguished by replacing cocaine infusions with saline infusions. Reinstatement of responding is then tested by administering a priming injection of cocaine.
描述:(由申请人提供) 该提案旨在研究性和雌激素对 大鼠自行静脉注射药物。四 动物模型将用于研究获取、维护、 调节/失调,以及恢复药物自我给药。这 性和雌激素对海洛因、甲基苯丙胺和甲基苯丙胺获取的影响 d, 1-3, 4-亚甲二氧基甲基苯丙胺 (MDMA) 自行给药 使用自动成形程序进行检查。渐进比率 (PR) 时间表 强化和需求行为经济分析将用于 评估性别和雌激素对维持可卡因和 海洛因自我给药。根据 PR 计划获得的断点 (BP) 测量值, 以及从需求曲线获得的斜率和 P-max 值将用于 评估几种剂量的可卡因和海洛因的增强功效。 可卡因自我给药的差异化途径将用于调查 性别对可卡因摄入调节/失调的影响。 将获得可卡因的剂量反应曲线以检查组间差异 剂量反应曲线的变化。雌激素对身体的影响 将使用启动检查来检查可卡因自我给药的恢复情况 药物恢复模型,其中按下药物的杠杆被熄灭 用盐水输注代替可卡因输注。恢复响应 然后通过注射可卡因来进行测试。

项目成果

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MEGAN E ROTH其他文献

MEGAN E ROTH的其他文献

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{{ truncateString('MEGAN E ROTH', 18)}}的其他基金

Primate Model of Drug Abuse: Gender and Hormonal Effects
药物滥用的灵长类动物模型:性别和激素影响
  • 批准号:
    6791919
  • 财政年份:
    2005
  • 资助金额:
    $ 2.5万
  • 项目类别:
Effects of Sex and Estrogen on Drug Self-Administration
性别和雌激素对药物自我给药的影响
  • 批准号:
    6515883
  • 财政年份:
    2002
  • 资助金额:
    $ 2.5万
  • 项目类别:

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摘除一只眼的白化大鼠生后早期视觉功能重组的生理和心理研究
  • 批准号:
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  • 财政年份:
    1988
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