Effects of Sex and Estrogen on Drug Self-Administration

性别和雌激素对药物自我给药的影响

• 批准号: 6515883
• 负责人: MEGAN E ROTH
• 金额: $ 0.95万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2002-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6515883
• 关键词: 3,4 methylenedioxymethamphetamine; albino rat; behavioral /social science research tag; behavioral habituation /sensitization; cocaine; dosage; drug addiction; estrogens; female; gender difference; heroin; hormone regulation /control mechanism; hormone therapy; intravenous administration; laboratory rat; male; methamphetamine; ovariectomy; psychological reinforcement; psychopharmacology; self medication; tamoxifen

DESCRIPTION: (provided by applicant) This proposal was designed to examine the effects of sex and estrogen on the self-administration of intravenously (i.v.) delivered drugs in rats. Four animal models will be used to investigate acquisition, maintenance, regulation/dysregulation, and reinstatement of drug self-administration. The effects of sex and estrogen on the acquisition of heroin, methamphetamine and d, 1-3, 4-methylenedioxymethamphetamine (MDMA) self-administration will be examined using an autoshaping procedure. A progressive ratio (PR) schedule of reinforcement and a behavioral economic analysis of demand will be used to evaluate the effects of sex and estrogen on the maintenance of cocaine and heroin self-administration. Breakpoint (BP) measures obtained on a PR schedule, along with slopes and P-max values obtained from demand curves will be used to evaluate the reinforcing efficacy of several doses of cocaine and heroin. Differential access to cocaine self-administration will be used to investigate the effect of sex on the regulation/dysregulation of cocaine intake. Dose-response curves for cocaine will be obtained to examine group differences in shifts in the dose-response curves. The effect of estrogen on the reinstatement of cocaine self-administration will be examined using a priming model of drug reinstatement in which lever pressing for drug is extinguished by replacing cocaine infusions with saline infusions. Reinstatement of responding is then tested by administering a priming injection of cocaine.

描述：（申请人提供） 这项提案旨在研究性和雌激素对 静脉内（i. v.）给老鼠注射药物四 动物模型将用于研究获取、维持， 调节/失调和恢复药物自我给药。的 性和雌激素对海洛因、甲基苯丙胺和 d，1-3，4-亚甲二氧基甲基苯丙胺（MDMA）自我给药将是 使用自动整形程序进行检查。累进比率（PR）时间表 强化和需求的行为经济分析将被用来 评估性别和雌激素对可卡因维持的影响， 海洛因自我给药根据PR计划获得的断点（BP）测量值， 沿着与斜率和从需求曲线获得的P-max值将被用于 评估几剂可卡因和海洛因的强化效果。 将使用可卡因自我给药的差异化机会来调查 性别对可卡因摄入调节/失调的影响。 将获得可卡因的剂量反应曲线以检查组间差异 剂量反应曲线的变化。雌激素对 可卡因自我给药的恢复将使用预激 药物恢复模型，其中通过以下方式消除对药物的杠杆按压 用生理盐水代替可卡因回复回复 然后通过注射可卡因来测试。

项目成果

Sex differences in the escalation of intravenous cocaine intake following long- or short-access to cocaine self-administration.

长期或短期自我给药可卡因后静脉注射可卡因摄入量增加的性别差异。

• DOI: 10.1016/j.pbb.2004.03.018
• 发表时间: 2004
• 期刊: Pharmacology, biochemistry, and behavior.
• 作者: Roth,MeganE;Carroll,MarilynE
• 通讯作者: Carroll,MarilynE