Photosynthetic manufacturing strategies for new biomaterials

我们的建筑环境面临着两个紧迫的挑战：解决城市生态系统中的空气和水污染问题，以及发明新的战略来减少建筑的资源足迹。该项目旨在通过将生长的材料融入我们的建筑环境的结构中，为生物集成设计创造蓝图。该博士学位旨在扩大制造过程，以创建第三代光合生物制造材料。愈伤组织是一团无组织的细胞，通常是通过去分化过程受伤的结果。与干细胞类似，愈伤组织在体外培养时具有产生植物的所有分化细胞和器官甚至整个植物的分化细胞和器官的能力。愈伤组织的可塑性和全能性的表达使得愈伤组织成为理想的生物材料和模型，以开发用于建筑环境的新型定制设计产品和系统。通过操纵植物生长激素，通过不同的生长速率在植物组织内出现几何形状。先前已经证明，单个植物细胞能够与3D打印支架相互作用，并且发现这些相互作用产生的生长类型和形态反映了比整个植物更大的复杂性。尽管在用于组织培养的生物制造支架的技术方面已经有了显著的进步，但是营养物的递送仍然是一个挑战。该项目将研究创建血管系统的新方法，以促进规模扩大。我们预见，专门适用于生物系统的先进制造和制造工具的开发将支持这一博士学位。生物化学工程和巴特利特之间的合作，该项目旨在缩小生物实验，生态学和建筑设计之间的差距。项目说明-确定一个模型系统的生物纤维素和愈伤组织生产和调查几何控制通过激素输送。通过构建原型开发生物材料生产的规模扩大战略，使用几何形状作为变量，以实现所需的湿度，光照和气候条件的环境条件，以实现更被动，低能耗的生长系统。创造新的制造方法，与生命系统大规模合作，以生产新材料。产出和成果-产出将包括原型，建造工作，试点研究，展览和科学出版物。

Our built environment has two urgent challenges: to address pollution of air and water within urban ecosystems, and to invent novel strategies to reduce the resource footprint of construction. This project aims create a blueprint for bio-integrated design by incorporating grown materials into the fabric of our built environment. This PhD aims to scale the manufacturing process for the creation of a 3rd generation of photosynthetically biofabricated materials to be produced. Callus is a mass of unorganised cells that often forms as a result of wounding through the process of dedifferentiation. Similar to stem cells, callus has the ability when cultivated invitro, to produce all the differentiated cells and organs of a plant and even that of the whole plant. The plasticity and the expression of totipotency makes callus an ideal biological material and model to develop novel custom designed products and systems for the built environment. Through manipulation of plant growth hormones geometry emerges within plant tissue through differential growth rates. It has been previously demonstrated that single plant cells are capable of interacting with 3D printed scaffolds, and the types of growth and morphologies arising from these interactions were found to reflect a greater complexity than that found in whole plants. Although there have been significant advances in technology to biofabricate scaffolds for tissue culture, the delivery of nutrients still remains a challenge. This project will investigate novel methods for the creation of vascular systems in order to facilitate scale up. We foresee that the development of advanced fabrication and manufacturing tools, specifically adapted for biological systems, will underpin this PhD. Working collaboratively between biochemical engineering and the Bartlett, this project aims to close the gap between biological experimentation, ecology and architectural design. PROJECT OBJECTIVES- Identification of a model system for biofabrication and callus production and investigation into geometric control through hormone delivery.- Development of a scale up strategy for biomaterial production through the construction of built prototypes, using geometry as a variable in order to achieve the desired environmental conditions for moisture, light exposure and climatic conditions, to enable more passive, low energy systems for growth.- Creation of novel fabrication methods to work with living systems at scale in order to produce new materials.OUTPUTS AND IMPACTS- Outputs will include prototypes, built work, pilot studies, exhibitions and scientific publications.