Dynamic fMRI to measure neuronal activity

描述（由申请人提供）：申请资金用于推进候选人Paul K. Maciejewski博士的研究生涯。该项目的总体目标是建立候选人，其之前的正式培训是机械工程和统计学，作为神经生理学和脑功能磁共振成像（fMRI）领域的独立研究者。研究职业发展计划包括教育/培训和研究部分。神经生理学教育将主要通过耶鲁大学医学院神经生物学研究生课程获得。在磁共振波谱（MRS）、磁共振成像（MRI）和代谢建模方面的培训将主要通过耶鲁大学代谢与生理学磁共振研究中心经验丰富的研究人员提供的培训获得。在研究中使用动物的道德教育和培训将主要通过耶鲁动物资源中心获得。研究计划有三个具体目标。这些研究包括：1)开发一种13C MRS方法来测量脑代谢耗氧量的动态变化；2)在大鼠模型中获得动态的、多模态的功能激活测量；3)开发一个血氧水平依赖（BOLD）信号和功能激活的神经血管模型。研究计划的目标将通过MRS、代谢建模、fMRI、电生理测量和动态建模的应用和扩展来实现。这项基础研究的结果有望与神经病学和精神病学的诊断评估相关。

DESCRIPTION (provided by applicant): Funding is requested to advance the research career of the Candidate, Dr. Paul K. Maciejewski. The overall aim of the project is to establish the Candidate, whose prior formal training has been in mechanical engineering and statistics, as an independent investigator in the areas of neurophysiology and brain functional magnetic resonance imaging (fMRI). The research career development plan consists of education/training and research components. Education in neurophysiology will be obtained primarily through courses offered in the Graduate Program in Neurobiology in the Yale University School of Medicine. Training in magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), and metabolic modeling will be obtained primarily through training provided by experienced researchers at the Yale University Magnetic Resonance Center for Research in Metabolism & Physiology. Education and training in the ethical use of animals in research will be obtained primarily through the Yale Animal Resources Center. The research plan has three Specific Aims. These are: 1) Developing a 13C MRS method for measuring dynamic changes in cerebral metabolic rate of oxygen consumption, 2) obtaining dynamic, multi-modal measurements of functional activation in a rat model, and 3) developing a neurovascular model of blood oxygenation level dependent (BOLD) signal and functional activation. The Aims of the research plan will be achieved through applications and extensions of MRS, metabolic modeling, fMRI, electrophysiological measurements, and dynamic modeling. The outcomes of this basic research are expected to be relevant to diagnostic evaluation in neurology and psychiatry.