Dynamic fMRI to measure neuronal activity

描述(由申请者提供)：为促进候选人保罗·K·马基耶夫斯基博士的研究事业，请提供资金。该项目的总体目标是将候选人确立为神经生理学和脑功能磁共振成像(FMRI)领域的独立研究员，他之前的正式培训是机械工程和统计学。研究职业发展计划由教育/培训和研究部分组成。神经生理学教育将主要通过耶鲁大学医学院神经生物学研究生计划提供的课程来获得。磁共振波谱(MRS)、磁共振成像(MRI)和代谢建模方面的培训将主要通过由耶鲁大学代谢与生理学研究磁共振中心的经验丰富的研究人员提供的培训来获得。有关在研究中合乎道德地使用动物的教育和培训将主要通过耶鲁动物资源中心获得。该研究计划有三个具体目标。它们是：1)建立测量大脑耗氧代谢率动态变化的~(13)C MRS方法；2)获得大鼠模型中功能激活的动态、多模式测量；以及3)建立血液氧合水平依赖(BOLD)信号和功能激活的神经血管模型。研究计划的目标将通过MRS、代谢建模、功能磁共振成像、电生理测量和动态建模的应用和扩展来实现。这项基础研究的结果预计将与神经学和精神病学的诊断评估相关。

DESCRIPTION (provided by applicant): Funding is requested to advance the research career of the Candidate, Dr. Paul K. Maciejewski. The overall aim of the project is to establish the Candidate, whose prior formal training has been in mechanical engineering and statistics, as an independent investigator in the areas of neurophysiology and brain functional magnetic resonance imaging (fMRI). The research career development plan consists of education/training and research components. Education in neurophysiology will be obtained primarily through courses offered in the Graduate Program in Neurobiology in the Yale University School of Medicine. Training in magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), and metabolic modeling will be obtained primarily through training provided by experienced researchers at the Yale University Magnetic Resonance Center for Research in Metabolism & Physiology. Education and training in the ethical use of animals in research will be obtained primarily through the Yale Animal Resources Center. The research plan has three Specific Aims. These are: 1) Developing a 13C MRS method for measuring dynamic changes in cerebral metabolic rate of oxygen consumption, 2) obtaining dynamic, multi-modal measurements of functional activation in a rat model, and 3) developing a neurovascular model of blood oxygenation level dependent (BOLD) signal and functional activation. The Aims of the research plan will be achieved through applications and extensions of MRS, metabolic modeling, fMRI, electrophysiological measurements, and dynamic modeling. The outcomes of this basic research are expected to be relevant to diagnostic evaluation in neurology and psychiatry.