Immune Mechanisms of Red Cell Alloimmunization
红细胞同种免疫的免疫机制
基本信息
- 批准号:6746014
- 负责人:
- 金额:$ 14.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-06-01 至 2006-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION
(Applicant's abstract) Dr. Sally Campbell-Lee is an African-American physician
who has completed fellowship training in Transfusion Medicine, and will be the
principal investigator on this award. Drs. Paul Ness and William Baldwin,
both of the Department of Pathology at Johns Hopkins, will serve as co-mentor
and primary mentor, respectively. The clinical and research programs at Johns
Hopkins Medical Institutions provide a rich environment for the growth and
development of young investigators, with many resources at their disposal.
Dr. Campbell-Lee's career goals are to become an independent investigator
specializing in immune mechanisms of allo-immunization in transfusion in
transfusion, in addition to serving as a medical director of a hospital blood
bank and transfusion medicine service. This award will aid in reaching this
goal by providing Dr. Campbell-Lee' with additional training in immunological
research methods, and the use of animal models in examining mechanisms of
alloimmunization, the application of which will provide insight into a
longstanding problem in transfusion medicine, that of immune modulation in the
transfusion recipient.
The research project will investigate immune mechanisms of red cell
alloimmunization in transfusion. When red blood cells (rbc) are transfused,
the recipient may become alloimmunized to foreign red cell antigens. When
alloimmunization occurs, the specificity of the antibody must be identified,
and blood must be found that lacks the corresponding antigen for that patient.
This is labor intensive and costly, and can cause a significant delay in the
availability of blood. In order to develop prevention or treatment for this
problem, immune mechanisms regulating antibody formation must be better
identified. We will study the following using a murine transfusion system:
the effects of eliminating or modifying targeted subpopulations of donor white
blood cells alloimmunization to rbc antigens; the effect of coating rbc for
transfusion with C3d on alloantibody formation, and the effect on red cell
alloantibody formation of modifying antigen presenting cells by blockage of
the CD28-B7 co-stimulatory pathway with CTLA41g.
描述
(申请人摘要)萨莉·坎贝尔-李博士是一位非裔美国医生
他已经完成了输血医学的奖学金培训,
这个奖项的主要研究者。 保罗·内斯和威廉·鲍德温博士
约翰霍普金斯病理学系的两位教授将担任共同导师
和主要导师 约翰斯的临床和研究项目
霍普金斯医疗机构提供了一个丰富的环境,
青年调查员的发展,有许多资源可供他们支配。
坎贝尔-李博士的职业目标是成为一名独立调查员
专门研究输血中同种免疫的免疫机制,
输血,除了担任医院血液的医疗主任
银行和输血医疗服务。 该奖项将有助于实现这一目标
通过为Campbell-Lee博士提供免疫学方面的额外培训,
研究方法,以及使用动物模型来检查
同种异体免疫,其应用将提供洞察,
长期存在的问题,输血医学,免疫调节,
输血接受者
该研究项目将研究红细胞的免疫机制
同种异体输血免疫 当输注红细胞时,
接受者可能对外来红细胞抗原产生同种免疫。 当
发生同种免疫时,必须鉴定抗体的特异性,
并且必须找到缺乏该患者的相应抗原的血液。
这是劳动密集型的并且成本高,并且可能导致在制造过程中的显著延迟。
血液的可用性。 为了预防或治疗这种疾病,
问题,调节抗体形成的免疫机制必须更好
鉴定 我们将使用鼠输血系统研究以下内容:
消除或修饰供体白色的靶向亚群的影响
红细胞抗原同种异体免疫的效果
C3 d对同种抗体形成及红细胞功能的影响
通过阻断抗原递呈细胞来修饰抗原递呈细胞的同种抗体形成
CD 28-B7与CTLA 41 g的共刺激通路。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Sally A Campbell-Lee其他文献
Sally A Campbell-Lee的其他文献
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