Functional Magnetic Resonance Studies in Schizophrenia

精神分裂症的功能磁共振研究

• 批准号: 6768850
• 负责人: JENNIFER E MCDOWELL
• 金额: $ 12.24万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-10 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6768850
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; brain disorder diagnosis; brain imaging /visualization /scanning; eye movements; family genetics; frontal lobe /cortex; functional magnetic resonance imaging; human subject; method development; neuroanatomy; neuroimaging; neuropathology; neuropsychology; patient oriented research; performance; prefrontal lobe /cortex; saccades; schizophrenia; visual fixation

DESCRIPTION: (provided by applicant) The long-term career goal of the primary investigator is to advance the knowledge ot schizophrenia-related functional neuropathology by establishing and directing a brain imaging laboratory. The short-term goal is to develop an expertise in the design, execution, and analysis of functional magnetic resonance imaging (fMRI) studies using a series of saccadic tasks. The realization of these goals will occur through a combination of intensive training and the completion of a systematic research plan over the course of the proposed funding period. Training in functional neuroimaging will occur within the UCSD functional neuroimaging group and during yearly 2-week training sessions at the NIMH. Training in neuroanatomy and neuropsychology will be completed within the UCSD neuroscience community. The research plan utilizes the P.I.'s existing studies on the saccadic performance of schizophrenia patients and their relatives as a foundation for generating and testing hypotheses of basal ganglia-thalamocortical circuitry dysfunction associated with schizophrenia. Schizophrenia patients perform normally on refixation saccade tasks, but demonstrate characteristic abnormalities on antisaccade and ocular motor delayed response tasks. A similar pattern of performance is observed among biological relatives of the patients, suggesting that this phenotype may be associated with the liability for developing schizophrenia. The pattern of saccadic performance is consistent with pathology of prefrontal cortex and its associated cortical and/or subcortical circuitry. This hypothesis may be tested using saccadic tasks as behavioral probes during fMRI to measure BOLD (blood oxygenation level dependent) signal change while subjects are engaged in ongoing behavioral and cognitive activity. Three specific aims are proposed; 1) evaluate the patterns of neural activation associated with refixation saccade performance in schizophrenia and normal subjects, 2) to test hypotheses of differing patterns of frontal activation between schizophrenia and normal groups during tasks that ostensibly require prefrontally-mediated inhibition (antisaccade and delayed response tasks), and 3) to test hypotheses of prefrontal cortex dysfunction among the biological relatives of schizophrenia patients.

描述：(申请人提供)小学教师的长期职业目标 研究人员将提高对精神分裂症相关功能的认识 通过建立和领导一个脑成像实验室来进行神经病理学研究。这个 短期目标是培养设计、执行和管理方面的专业知识 功能性磁共振成像(FMRI)研究的系列分析 扫视任务。这些目标的实现将通过一个 强化训练与完成系统研究相结合 在拟议的资助期内制定计划。 功能神经成像的培训将在加州大学圣迭戈分校的 神经影像组，每年在NIMH进行为期两周的训练。 神经解剖学和神经心理学方面的培训将在加州大学圣迭戈分校完成 神经科学界。研究计划利用P.I.S已有的研究 精神分裂症患者及其亲属的眼球跳动表现 基本假设的生成和检验基础 与精神分裂症相关的神经节-丘脑皮质回路功能障碍。 精神分裂症患者在重新注视眼跳任务中表现正常，但 在眼球跳动和眼球运动方面表现出特征性异常 延迟响应任务。类似的表现模式也出现在 患者的亲缘关系，表明这种表型可能是 与罹患精神分裂症的风险有关。的模式 眼球跳动表现与前额叶皮质的病理特征一致。 相关的皮质和/或皮质下回路。这一假设可能会得到检验。 在fMRI测量BOLD(血液)过程中使用扫视任务作为行为探测器 氧合水平相关)信号在受试者参与时发生变化 正在进行的行为和认知活动。 提出了三个具体目标：1)评价神经激活模式 精神分裂症患者和正常人的再注视眼跳表现 受试者，2)检验不同额叶激活模式的假说 精神分裂症患者和正常人群之间的差异 前额叶介导的抑制(抗眼跳和延迟反应任务)，以及 3)检验前额叶皮质功能障碍的生物学假说。 精神分裂症患者的亲属。