Functional Magnetic Resonance Studies in Schizophrenia

精神分裂症的功能磁共振研究

• 批准号: 6528108
• 负责人: JENNIFER E MCDOWELL
• 金额: $ 11.85万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-10 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6528108
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; brain disorder diagnosis; brain imaging /visualization /scanning; eye movements; family genetics; frontal lobe /cortex; functional magnetic resonance imaging; human subject; method development; neuroanatomy; neuroimaging; neuropathology; neuropsychology; patient oriented research; performance; prefrontal lobe /cortex; saccades; schizophrenia; visual fixation

DESCRIPTION: (provided by applicant) The long-term career goal of the primary investigator is to advance the knowledge ot schizophrenia-related functional neuropathology by establishing and directing a brain imaging laboratory. The short-term goal is to develop an expertise in the design, execution, and analysis of functional magnetic resonance imaging (fMRI) studies using a series of saccadic tasks. The realization of these goals will occur through a combination of intensive training and the completion of a systematic research plan over the course of the proposed funding period. Training in functional neuroimaging will occur within the UCSD functional neuroimaging group and during yearly 2-week training sessions at the NIMH. Training in neuroanatomy and neuropsychology will be completed within the UCSD neuroscience community. The research plan utilizes the P.I.'s existing studies on the saccadic performance of schizophrenia patients and their relatives as a foundation for generating and testing hypotheses of basal ganglia-thalamocortical circuitry dysfunction associated with schizophrenia. Schizophrenia patients perform normally on refixation saccade tasks, but demonstrate characteristic abnormalities on antisaccade and ocular motor delayed response tasks. A similar pattern of performance is observed among biological relatives of the patients, suggesting that this phenotype may be associated with the liability for developing schizophrenia. The pattern of saccadic performance is consistent with pathology of prefrontal cortex and its associated cortical and/or subcortical circuitry. This hypothesis may be tested using saccadic tasks as behavioral probes during fMRI to measure BOLD (blood oxygenation level dependent) signal change while subjects are engaged in ongoing behavioral and cognitive activity. Three specific aims are proposed; 1) evaluate the patterns of neural activation associated with refixation saccade performance in schizophrenia and normal subjects, 2) to test hypotheses of differing patterns of frontal activation between schizophrenia and normal groups during tasks that ostensibly require prefrontally-mediated inhibition (antisaccade and delayed response tasks), and 3) to test hypotheses of prefrontal cortex dysfunction among the biological relatives of schizophrenia patients.

描述：（由申请人提供）主要的长期职业目标 研究者将提高对精神分裂症相关功能的认识 神经病理学通过建立和指导脑成像实验室。的 短期目标是发展在设计，执行， 使用一系列功能磁共振成像（fMRI）研究分析 扫视任务。这些目标的实现将通过 强化训练与完成系统研究相结合 在拟议的供资期内， 功能性神经成像的培训将在UCSD功能性 神经影像学组和在每年2周的培训课程在NIMH。 神经解剖学和神经心理学的培训将在UCSD内完成 神经科学社区研究计划利用P.I.现有研究 精神分裂症患者及其亲属的扫视表现， 产生和检验基本假设的基础 与精神分裂症相关的神经节-丘脑皮质回路功能障碍 精神分裂症患者在再注视扫视任务中表现正常，但 显示出在逆滑跑和眼球运动方面的特征性异常 延迟响应任务。类似的表现模式被观察到， 患者的生物学亲属，这表明这种表型可能是 与发展成精神分裂症的可能性有关。的格局 扫视表现与前额叶皮层的病理学及其 相关的皮质和/或皮质下电路。这一假设可以得到检验 使用扫视任务作为fMRI期间的行为探针来测量BOLD（血液 氧合水平依赖性）信号变化 持续的行为和认知活动 提出了三个具体目标：1）评估神经激活模式 与精神分裂症患者和正常人的再注视扫视表现相关 受试者，2）测试不同模式的额叶激活的假设 精神分裂症患者和正常人之间的差异 前额叶介导的抑制（反跳跃和延迟反应任务），以及 3)为了验证前额叶皮层功能障碍的假设， 精神分裂症患者的亲属。