Characterising competitive interactions and binding selectivity at bio-nano interfaces

当开发靶向癌症生物传感器时，目标是创造尽可能有选择性的探针，以帮助准确检测疾病。这可以通过使用可以同时与多个目标相互作用的探针来大大增强，称为多价。与健康细胞相比，许多癌细胞在其膜表面表现出CD44蛋白表达的增加。在这项研究中，声学技术被用来表征CD44蛋白包被的生物膜与功能化金表面的多价相互作用。收集到的结合信息将用于理论模型的开发，这些模型将用于设计高选择性CD44靶向生物传感器。

When developing targeted cancer biosensors, the aim is to create probes that are as selective as possible to aid in accurate disease detection. This can be greatly enhanced through the use of probes that can interact with more than one target simultaneously, dubbed multivalency. Many cancer cells exhibit an increase in the expression of the CD44 protein at their membrane surface in comparison to healthy cells. In this study, acoustic techniques are used to characterise the multivalent interactions of CD44 protein coated biological membranes with functionalised gold surfaces. The binding information collected will be used in the development of theoretical models that will feed into the design of highly selective CD44 targeting biosensors.