Engineering a sugar aminotransferase for the sustainable production of high-value chiral compounds

设计糖转氨酶以可持续生产高价值手性化合物

• 批准号: 2422568
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2422568
• 关键词: Engineering; sugar; aminotransferase; sustainable; production

The project will involve the development of a panel of enzymes with activity on renewable sugar substrates. These enzymes will be engineered to accept a wide range of sugars and convert them to valuable chiral compounds, which are extremely challenging to access using more traditional synthetic chemistry approaches. The research will involve engineering enzymes to broaden their substrate scope and applying these designer biocatalysts for the synthesis of chiral molecules. The project is in collaboration with BASF who are interested in developing enzymes for synthetic applications.

该项目将涉及开发一种在可再生糖基质上具有活性的酶。这些酶的设计将接受广泛的糖类，并将它们转化为有价值的手性化合物，使用更传统的合成化学方法获取这些化合物极具挑战性。这项研究将涉及工程酶以扩大其底物范围，并将这些设计的生物催化剂应用于手性分子的合成。该项目是与巴斯夫合作的，巴斯夫对开发用于合成应用的酶感兴趣。