Tissue-engineering Valve from Cell-Remodeled Biopolymer
Tissue-engineering Valve from Cell-Remodeled Biopolymer
批准号:
6748445
负责人:
ROBERT T TRANQUILLO
金额:
$74.38万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2003
资助国家:
美国
项目状态:
已结题
起止时间:
2003-06-01 至 2008-05-31
关键词:
bioengineering /biomedical engineeringbiomaterial compatibilitybiomaterial development /preparationbiomaterialsbiomechanicsfluid flowgelheart functionheart valvesmedical implant sciencemodel design /developmentphysical modelprosthetic heart valvestem cellsswinetechnology /technique developmentthree dimensional imaging /topographytissue /cell culturetissue engineeringtissue support frameultrasonographyvascular endothelium
中文摘要
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英文摘要
DESCRIPTION (provided by applicant): This BRP aims to develop a tissue-engineered cardiovascular valve, with the initial focus being an aortic valve replacement. The "tissue-equivalent" approach to fabricating bioartificial tissues, in which a fibrillar biopolymer gel (type I collagen or fibrin) is contracted, aligned, and remodeled by entrapped tissue cells, will be used. A tissue mechanical theory will be applied to determine the optimal mold design such that cell-mediated compaction of the gel around the mold surfaces yields the target geometry and ECM fiber alignment. A coupled solid fluid mechanical model of valve function in pulsatile flow will be used to define what alignment-dependent mechanical properties of our "valve-equivalent" (VE)are desired following incubation for proper valve function, and to simulate what the VE function will be. Various experimental strategies will be implemented to manipulate these properties during incubation. High-speed ultrasonic imaging of leaflet motion will be developed and used along with particle imaging velicometry in order to validate the model as well as visualize valve function. In addition to comprehensive biological and biomechanical characterization of the VE, novel adult stem cells will be assessed as a source of endothelial cells and, potentially, interstitial leaflet cells for VE fabrication.
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