Completely biological tissue-engineered pulmonic valve grown in vitro from human cells for pediatric patients
完全生物组织工程肺动脉瓣,由人体细胞在体外培养,供儿科患者使用
基本信息
- 批准号:10188591
- 负责人:
- 金额:$ 72.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-04-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAddressAdolescentAdultAnimal ModelAreaBiochemicalBiologicalBiological AssayCaliberCardiac Surgery proceduresCellsCellularityChildChildhoodClinicalCodeCommissureComputer-Aided DesignConsensusDataDefectDimensionsDropsElementsEngineeringEnsureFaceFailureFibroblastsFundingGeometryGoalsGrowthHarvestHeart ValvesHistologyHumanImmunohistochemistryImplantIn SituIn VitroLengthLiquid substanceLongitudinal StudiesLungMeasurementMeasuresModelingMonitorOutcomes ResearchPatientsPerformancePhenotypePhysiologic pulsePlant RootsPositioning AttributePre-Clinical ModelPreclinical TestingPulmonary artery structurePulmonary valve structureSheepSiteSkinSolidSterilityStressStructureSurfaceSurgical suturesSystemSystolic PressureTestingTimeTissue EngineeringTissuesTranslationsTubeUltrasonographyValidationaortic valveaortic valve disorderaortic valve replacementbasecardiac tissue engineeringclinically relevantconditioningdesignexperiencehemodynamicsimplantationlamb modelmechanical propertiesnovelpediatric patientspressureshear stresssheep modelsuccess
项目摘要
Abstract
The goal of this project is to create a heart valve that can grow with children and never require replacement.
Using a biologically-engineered collagenous matrix in the form of a tube that has been shown to grow as a
pulmonary artery replacement in lambs, and a novel design for a heart valve made from these tubes and
degradable suture that confers durable commissures as well as valve growth potential, we will design,
optimize, test, and implant tri-tube valves in a juvenile sheep model to demonstrate valve growth. Aim 1 will
use computer-aided design (a fluid-structure interaction model for valve opening and finite element model for
the closed valve state) to screen combinations of design parameters (defining coaptation area and geometry)
for efficient valve function, Aim 2 will test the optimal designs in a pulse duplicator and validate/refine the CAD
models, and Aim 3 will involve studies of the valve in growing juvenile sheep. Long-term studies of pulmonary
and aortic valve replacement are designed with measurements to rigorously address valve growth.
摘要
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
6-month aortic valve implantation of an off-the-shelf tissue-engineered valve in sheep.
- DOI:10.1016/j.biomaterials.2015.09.016
- 发表时间:2015-12
- 期刊:
- 影响因子:14
- 作者:Syedain Z;Reimer J;Schmidt J;Lahti M;Berry J;Bianco R;Tranquillo RT
- 通讯作者:Tranquillo RT
Pediatric tubular pulmonary heart valve from decellularized engineered tissue tubes.
- DOI:10.1016/j.biomaterials.2015.05.009
- 发表时间:2015-09
- 期刊:
- 影响因子:14
- 作者:Reimer, Jay M.;Syedain, Zeeshan H.;Haynie, Bee H. T.;Tranquillo, Robert T.
- 通讯作者:Tranquillo, Robert T.
Cyclic Stretch and Perfusion Bioreactor for Conditioning Large Diameter Engineered Tissue Tubes.
- DOI:10.1007/s10439-015-1437-x
- 发表时间:2016-05
- 期刊:
- 影响因子:3.8
- 作者:Schmidt JB;Tranquillo RT
- 通讯作者:Tranquillo RT
Tissue engineering of acellular vascular grafts capable of somatic growth in young lambs.
- DOI:10.1038/ncomms12951
- 发表时间:2016-09-27
- 期刊:
- 影响因子:16.6
- 作者:Syedain, Zeeshan;Reimer, Jay;Lahti, Matthew;Berry, James;Johnson, Sandra;Tranquillo, Robert T.
- 通讯作者:Tranquillo, Robert T.
Effects of Intermittent and Incremental Cyclic Stretch on ERK Signaling and Collagen Production in Engineered Tissue.
- DOI:10.1007/s12195-015-0415-6
- 发表时间:2016-03-01
- 期刊:
- 影响因子:2.8
- 作者:Schmidt JB;Chen K;Tranquillo RT
- 通讯作者:Tranquillo RT
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ROBERT T TRANQUILLO其他文献
ROBERT T TRANQUILLO的其他文献
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{{ truncateString('ROBERT T TRANQUILLO', 18)}}的其他基金
Biologically-engineered Transcatheter Vein Valve: Design Optimization and Preclinical Testing
生物工程经导管静脉瓣膜:设计优化和临床前测试
- 批准号:
10594865 - 财政年份:2023
- 资助金额:
$ 72.11万 - 项目类别:
Completely biological tissue-engineered pulmonic valve grown in vitro from human
从人体体外培养的完全生物组织工程肺动脉瓣
- 批准号:
8083856 - 财政年份:2011
- 资助金额:
$ 72.11万 - 项目类别:
Biopolymer-guided human stem cell assembly for engineered myocardium
生物聚合物引导的人类干细胞组装用于工程化心肌
- 批准号:
8328585 - 财政年份:2011
- 资助金额:
$ 72.11万 - 项目类别:
Perfusable and beating engineered myocardium from human progenitor cells based on
基于人类祖细胞的可灌注和跳动工程心肌
- 批准号:
8138261 - 财政年份:2011
- 资助金额:
$ 72.11万 - 项目类别:
Tissue-engineered pulmonic valve grown from human cells for pediatric patients
由人体细胞培育而成的组织工程肺动脉瓣,供儿科患者使用
- 批准号:
8527302 - 财政年份:2011
- 资助金额:
$ 72.11万 - 项目类别:
Completely biological tissue-engineered pulmonic valve grown in vitro from human cells for pediatric patients
完全生物组织工程肺动脉瓣,由人体细胞在体外培养,供儿科患者使用
- 批准号:
9520733 - 财政年份:2011
- 资助金额:
$ 72.11万 - 项目类别:
Tissue-engineered pulmonic valve grown from human cells for pediatric patients
由人体细胞培育而成的组织工程肺动脉瓣,供儿科患者使用
- 批准号:
8242099 - 财政年份:2011
- 资助金额:
$ 72.11万 - 项目类别:
Biopolymer-guided human stem cell assembly for engineered myocardium
生物聚合物引导的人类干细胞组装用于工程化心肌
- 批准号:
8529260 - 财政年份:2011
- 资助金额:
$ 72.11万 - 项目类别:
Tissue-engineered pulmonic valve grown from human cells for pediatric patients
由人体细胞培育而成的组织工程肺动脉瓣,供儿科患者使用
- 批准号:
8649073 - 财政年份:2011
- 资助金额:
$ 72.11万 - 项目类别:
Tissue-engineered pulmonic valve grown from human cells for pediatric patients
由人体细胞培育而成的组织工程肺动脉瓣,供儿科患者使用
- 批准号:
8828279 - 财政年份:2011
- 资助金额:
$ 72.11万 - 项目类别:
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