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Completely biological tissue-engineered pulmonic valve grown in vitro from human cells for pediatric patients

完全生物组织工程肺动脉瓣，由人体细胞在体外培养，供儿科患者使用

基本信息

批准号：
10188591
负责人：
ROBERT T TRANQUILLO
金额：
$ 72.11万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10188591
关键词：
3-Dimensional Address Adolescent Adult Animal Model Area Biochemical Biological Biological Assay Caliber Cardiac Surgery procedures Cells Cellularity Child Childhood Clinical Code Commissure Computer-Aided Design Consensus Data Defect Dimensions Drops Elements Engineering Ensure Face Failure Fibroblasts Funding Geometry Goals Growth Harvest Heart Valves Histology Human Immunohistochemistry Implant In Situ In Vitro Length Liquid substance Longitudinal Studies Lung Measurement Measures Modeling Monitor Outcomes Research Patients Performance Phenotype Physiologic pulse Plant Roots Positioning Attribute Pre-Clinical Model Preclinical Testing Pulmonary artery structure Pulmonary valve structure Sheep Site Skin Solid Sterility Stress Structure Surface Surgical sutures System Systolic Pressure Testing Time Tissue Engineering Tissues Translations Tube Ultrasonography Validation aortic valve aortic valve disorder aortic valve replacement base cardiac tissue engineering clinically relevant conditioning design experience hemodynamics implantation lamb model mechanical properties novel pediatric patients pressure shear stress sheep model success

项目摘要

Abstract The goal of this project is to create a heart valve that can grow with children and never require replacement. Using a biologically-engineered collagenous matrix in the form of a tube that has been shown to grow as a pulmonary artery replacement in lambs, and a novel design for a heart valve made from these tubes and degradable suture that confers durable commissures as well as valve growth potential, we will design, optimize, test, and implant tri-tube valves in a juvenile sheep model to demonstrate valve growth. Aim 1 will use computer-aided design (a fluid-structure interaction model for valve opening and finite element model for the closed valve state) to screen combinations of design parameters (defining coaptation area and geometry) for efficient valve function, Aim 2 will test the optimal designs in a pulse duplicator and validate/refine the CAD models, and Aim 3 will involve studies of the valve in growing juvenile sheep. Long-term studies of pulmonary and aortic valve replacement are designed with measurements to rigorously address valve growth.

摘要该项目的目标是创造一种可以与儿童一起成长并且永远不需要更换的心脏瓣膜。使用一种生物工程化的胶原基质，以一种管的形式，已经显示出作为一种细胞生长，肺动脉置换术，以及由这些管制成的心脏瓣膜的新设计，可降解缝线，赋予持久的连合以及瓣膜生长潜力，我们将设计，在幼年绵羊模型中优化、测试和植入三管瓣膜，以证明瓣膜生长。目标1将使用计算机辅助设计（阀门开启的流体-结构相互作用模型和关闭的瓣膜状态）以筛选设计参数的组合（限定接合面积和几何形状）为了有效地发挥阀门的功能，目标2将在脉冲复制器中测试最佳设计，并验证/改进计算机辅助设计目标3将涉及在成长中的幼年绵羊中研究瓣膜。肺部的长期研究和主动脉瓣置换术设计有严格解决瓣膜生长的测量。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

6-month aortic valve implantation of an off-the-shelf tissue-engineered valve in sheep.

DOI：
10.1016/j.biomaterials.2015.09.016
发表时间：
2015-12
期刊：
Biomaterials
影响因子：
14
作者：
Syedain Z;Reimer J;Schmidt J;Lahti M;Berry J;Bianco R;Tranquillo RT
通讯作者：
Tranquillo RT

Pediatric tubular pulmonary heart valve from decellularized engineered tissue tubes.

DOI：
10.1016/j.biomaterials.2015.05.009
发表时间：
2015-09
期刊：
BIOMATERIALS
影响因子：
14
作者：
Reimer, Jay M.;Syedain, Zeeshan H.;Haynie, Bee H. T.;Tranquillo, Robert T.
通讯作者：
Tranquillo, Robert T.

Cyclic Stretch and Perfusion Bioreactor for Conditioning Large Diameter Engineered Tissue Tubes.

DOI：
10.1007/s10439-015-1437-x
发表时间：
2016-05
期刊：
Annals of biomedical engineering
影响因子：
3.8
作者：
Schmidt JB;Tranquillo RT
通讯作者：
Tranquillo RT

Tissue engineering of acellular vascular grafts capable of somatic growth in young lambs.

DOI：
10.1038/ncomms12951
发表时间：
2016-09-27
期刊：
NATURE COMMUNICATIONS
影响因子：
16.6
作者：
Syedain, Zeeshan;Reimer, Jay;Lahti, Matthew;Berry, James;Johnson, Sandra;Tranquillo, Robert T.
通讯作者：
Tranquillo, Robert T.

Effects of Intermittent and Incremental Cyclic Stretch on ERK Signaling and Collagen Production in Engineered Tissue.