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LifeBelt CPR: Combined Thoracic and Sternal Compression

LifeBelt CPR：胸部和胸骨联合按压

基本信息

批准号：
6641971
负责人：
Thomas Lach
金额：
$ 15.15万
依托单位：
DECA-MEDICS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-05-05 至 2004-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): In the United States, more than 250,000 persons annually experience out-of-hospital sudden cardiac death (SCD). However, few, approximately 4%, are revived with standard CPR and advanced life support interventions and survive to be discharged from the hospital. Successful restoration of cardiac function after SCD is dependent on early electrical defibrillation in patients found to be in ventricular fibrillation (VF) and early provision of effective artificial circulation and ventilation, i.e., CPR. However, standard CPR, as currently practiced, provides only 10-20% of normal cardiac output. The purpose of this project is to evaluate the effectiveness of a new manual CPR device that provides sequential thoracic and sternal (cardiac) compression. The specific aims of the project include defining the mechanism of blood flow produced by the device, measuring intravascular pressures, blood flow, and ventilation during prolonged CPR with the device, and evaluating short-term outcome when the device is compared to standard manual CPR. All studies will be undertaken in the research laboratory and design modifications of the device will be made based upon laboratory observations. The mechanism of blood flow will be assessed with pressure synchronized cine-angiography, transesophageal 2-D Doppler echocardiography, and high-fidelity hemodynamic measurements. Cardiac output, coronary perfusion pressure, and ventilation produced by the device will be evaluated in an animal model of VF cardiac arrest and resuscitation. The new CPR device will be compared to conventional manual CPR with a study end-point of short-term outcome and survival for three hours. The long-term objective of the project is the production of a simple manual CPR device that will produce greater blood flow than standard CPR, negate the need for mouth-to-mouth ventilation, and that can be used by the lay person with minimal instruction. The device could easily be deployed with existing automatic external defibrillators (AEDs), which provide brief and simple audio instruction regarding use. Use of early and effective CPR with the new device preceding or following early defibrillation attempts by lay persons (public access defibrillation) could result in more lives saved.

描述（由申请人提供）：在美国，每年有超过250，000人经历院外心脏性猝死（SCD）。然而，只有少数人（约4%）通过标准CPR和先进的生命支持干预措施复苏，并存活出院。SCD后心脏功能的成功恢复取决于发现处于室颤（VF）中的患者的早期电除颤和早期提供有效的人工循环和通气，即，心肺复苏然而，目前实施的标准CPR仅提供正常心输出量的10-20%。本项目的目的是评价一种新的手动CPR设备的有效性，该设备提供连续的胸部和胸骨（心脏）按压。该项目的具体目标包括定义该设备产生的血流机制，在使用该设备进行长时间CPR期间测量血管内压力、血流和通气量，并在将该设备与标准手动CPR进行比较时评估短期结果。所有研究将在研究实验室进行，并将根据实验室观察结果对器械进行设计修改。血流机制将通过压力同步电影血管造影术、经食管二维多普勒超声心动图和高保真血流动力学测量进行评估。将在VF心脏骤停和复苏的动物模型中评价器械产生的心输出量、冠状动脉灌注压和通气。新的CPR设备将与传统的手动CPR进行比较，研究终点是短期结果和三小时的生存率。该项目的长期目标是生产一种简单的手动心肺复苏术设备，该设备将产生比标准心肺复苏术更大的血流量，无需口对口通气，并且可以由非专业人员使用最少的指导。该设备可以很容易地与现有的自动体外除颤器（AED）一起部署，这些自动体外除颤器提供了关于使用的简短和简单的音频说明。在外行人早期除颤尝试之前或之后使用新设备进行早期有效的CPR（公共访问除颤）可能会挽救更多的生命。