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Life Belt CPR: Sternal Compression and Thoracic Constraint

救生带 CPR：胸骨按压和胸廓约束

基本信息

批准号：
7121943
负责人：
Thomas Lach
金额：
$ 47.46万
依托单位：
DECA-MEDICS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-07-01 至 2009-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): In the United States, more than 250,000 persons annually experience out-of-hospital sudden cardiac death (SCD). However, few, approximately 4%, are revived with standard CPR and advanced life support interventions and survive to be discharged from the hospital. Successful restoration of cardiac function after SCD is dependent on early electrical defibrillation in patients found to be in ventricular fibrillation (VF) and early provision of effective artificial circulation and ventilation, i.e., CPR. However, standard CPR, as currently practiced, provides only 10-20% of normal cardiac output and low coronary perfusion pressures; and is usually ineffectively performed. A new manual CPR device has been developed and tested in a Phase I STTR. The Phase I study of the LifeBelt(tm) device defined the mechanism of blood flow with the device during cardiac arrest, defined optimal performance parameter for the device, served to stimulate early revisions in the design of the device, and demonstrated efficacy for resuscitation from prolonged cardiac arrest and short-term survival. The specific aims of this Phase II application are a logical extension of the Phase I study: Aim 1: To convert the existing prototype device to a "second generation" pre-production model that replicates the function of the prototype but which is light weight, made of inexpensive material, and easily produced in quantity. This will be accomplished through collaboration with a mechanical/bioengineering team. Aim 2: To compare the second generation device to standard manual CPR, using manikin simulators, for "ease of use" characteristics in different "rescuer" populations. These rescuers will include physicians, nurses, paramedics, and lay persons. Aim 3: To compare long-term (72 hour) neurologic outcome after prolonged cardiac arrest and resuscitation with the LifeBelt(tm) device versus manual CPR in a swine model. The long-term objective of the project is the production of a simple manual CPR device that will produce greater blood flow than standard CPR, minimize the need for mouth-to-mouth ventilation, and that can be used by the lay person with minimal instruction. The device could easily be deployed with existing automatic external defibrillators (AEDs) which provide brief and simple audio instruction regarding use. Use of early and effective CPR with the new device preceding or following early defibrillation attempts by lay persons (public access defibrillation) could result in more lives saved.

描述（由申请人提供）：在美国，每年有超过250，000人经历院外心脏性猝死（SCD）。然而，只有少数人（约4%）通过标准CPR和先进的生命支持干预措施复苏，并存活出院。SCD后心脏功能的成功恢复取决于发现处于室颤（VF）中的患者的早期电除颤和早期提供有效的人工循环和通气，即，心肺复苏然而，目前实施的标准CPR仅提供正常心输出量的10-20%和低冠状动脉灌注压;并且通常不能有效地执行。一种新的手动CPR设备已经开发出来，并在第一阶段STTR中进行了测试。LifeBeltTM装置的I期研究确定了心脏骤停期间装置的血流机制，确定了装置的最佳性能参数，用于刺激装置设计的早期修改，并证明了从长期心脏骤停和短期存活中复苏的功效。第二阶段申请的具体目标是第一阶段研究的逻辑延伸：目标1：将现有原型设备转换为“第二代”预生产模型，该模型复制原型的功能，但重量轻，由廉价材料制成，易于大量生产。这将通过与机械/生物工程团队合作来完成。目标二：使用人体模型模拟器比较第二代器械与标准手动CPR在不同“救援者”人群中的“易用性”特征。这些救援人员将包括医生、护士、护理人员和非专业人员。目标三：在猪模型中比较使用LifeBelt（tm）装置与手动CPR进行长时间心脏骤停和复苏后的长期（72小时）神经学结局。该项目的长期目标是生产一种简单的手动CPR设备，该设备将产生比标准CPR更大的血流量，最大限度地减少口对口通气的需要，并且可以由外行人使用最少的指导。该设备可以很容易地与现有的自动体外除颤器（AED）一起部署，这些自动体外除颤器提供了关于使用的简短和简单的音频说明。在外行人早期除颤尝试之前或之后使用新设备进行早期有效的CPR（公共访问除颤）可能会挽救更多的生命。