Smart biomaterial composites with hierarchical architecture for ligament repair and regeneration

该项目涉及临床输入，并通过检查前交叉韧带重建手术患者的韧带组织来绘制与年龄相关的组织特征和分化。我们将讨论韧带组织的分层多尺度物理结构对力学性能的影响。我们可以用简单的多糖如纤维素和几丁质在二维和三维中模拟胶原蛋白的复杂层次顺序吗？如何处理和优化多尺度有序纤维结构以获得最佳机械性能？生物打印具有多尺度（宏-微-纳米）结构的3D细胞结构是否可能？它如何改善移植物的长期生物力学性能？

The project involves clinical input and a real opportunity to map age related tissue profiling and differentiation via examining ligament tissues from patients that goes under ACL reconstruction surgery.We will address the influence of the hierarchical multi-scale physical construct of the ligament tissue on the mechanical properties.Can we use the mimic such complex hierarchical order in of the collagen using simple polysaccharides such as cellulose and chitin in 2D and 3D?How do multiscale ordered fibrillar structures need to be processed and optimized to give optimum mechanical properties?Is it possible to bioprint 3D cellular constructs with multiscale (macro-micro-nano) architectures and how does that improve the long-term biomechanical performance of the graft?