Smart biomaterial composites with hierarchical architecture for ligament repair and regeneration

该项目涉及临床投入和通过检查接受前交叉韧带重建手术的患者的韧带组织来绘制与年龄相关的组织特征和分化图的真正机会。我们将解决韧带组织的分级多尺度物理结构对力学特性的影响。我们能否在2D和3D中使用简单的多糖如纤维素和甲壳素来模拟胶原的这种复杂的分级顺序？如何处理和优化多尺度有序的纤维结构以提供最佳的机械性能？是否有可能用多尺度(宏观-微观-纳米)结构来生物打印3D细胞结构，以及这如何改善移植物的长期生物力学性能？

The project involves clinical input and a real opportunity to map age related tissue profiling and differentiation via examining ligament tissues from patients that goes under ACL reconstruction surgery.We will address the influence of the hierarchical multi-scale physical construct of the ligament tissue on the mechanical properties.Can we use the mimic such complex hierarchical order in of the collagen using simple polysaccharides such as cellulose and chitin in 2D and 3D?How do multiscale ordered fibrillar structures need to be processed and optimized to give optimum mechanical properties?Is it possible to bioprint 3D cellular constructs with multiscale (macro-micro-nano) architectures and how does that improve the long-term biomechanical performance of the graft?