Smart biomaterial composites with hierarchical architecture for ligament repair and regeneration

该项目涉及临床输入和一个真实的机会，通过检查ACL重建手术患者的韧带组织，绘制与年龄相关的组织轮廓和分化。我们能不能用简单的多糖如纤维素和甲壳素来模拟这种复杂的胶原蛋白的层次结构，2D和3D？如何加工和优化多尺度有序纤维结构以获得最佳机械性能？生物打印具有多尺度（宏-微-纳米）结构的3D细胞结构是否可能，以及这如何改善移植物的长期生物力学性能？

The project involves clinical input and a real opportunity to map age related tissue profiling and differentiation via examining ligament tissues from patients that goes under ACL reconstruction surgery.We will address the influence of the hierarchical multi-scale physical construct of the ligament tissue on the mechanical properties.Can we use the mimic such complex hierarchical order in of the collagen using simple polysaccharides such as cellulose and chitin in 2D and 3D?How do multiscale ordered fibrillar structures need to be processed and optimized to give optimum mechanical properties?Is it possible to bioprint 3D cellular constructs with multiscale (macro-micro-nano) architectures and how does that improve the long-term biomechanical performance of the graft?