Bio-tribo-corrosion resistant 3D Printed Composites for Load-bearing Implants

用于承重植入物的生物耐摩擦腐蚀 3D 打印复合材料

• 批准号: 10565931
• 负责人: AMIT BANDYOPADHYAY
• 金额: $ 32.08万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10565931
• 关键词: 3D Print; Alloys; Aluminum Oxide; Articulation; Biological; Blindness; Cattle; Cells; Ceramics; Clinical; Corrosion; Data; Distal; Failure; Femur; Fibroblasts; Film; Fracture; Frequencies; Generations; Goals; Head; Hip region structure; Human; Immune; Impaired Renal Function; Implant; In Situ; In Vitro; Intervention; Ions; Knowledge; Lasers; Life; Lubricants; Measures; Mechanics; Mediating; Medical; Metals; Modeling; Oryctolagus cuniculus; Osteoblasts; Probability; Process; Property; Psychological reinforcement; Reaction; Research; Resistance; Second Look Surgery; Serum; Solid; Surface; Symptoms; Synovial Membrane; System; Testing; Tissues; Translations; Walking; Weight; Weight-Bearing state; Work; biomaterial compatibility; bone; calcium phosphate; cell injury; clinically relevant; deafness; design; femur head; healing; hip replacement arthroplasty; implant design; improved; in vitro testing; in vivo; innovation; interstitial cell; manufacture; novel; programs; response; stem; success; successful intervention

Among load-bearing implants, total hip arthroplasty (THA) is probably the most clinically successful intervention. CoCrMo alloy, a wear resistant material of choice, is typically used in femoral heads for THAs. In vivo life of THAs are often reduced due to debris generation, and Co and Cr metal ion release from modular junctions. Management of taper corrosion from trunnions of CoCrMo head and Ti6Al4V stems remain a serious challenge today. Taper corrosion happens primarily due to mechanically assisted crevice corrosion (MACC) along with fretting and galvanic corrosion, and leads to adverse local tissue reactions (ALTR), an immune- mediated biological reaction due to elevated Co and Cr ions. ALTR has profound influence on bone, leading to implant failure, which can result in early revision surgery. Co and Cr ions can also cause other symptoms such as deafness, blindness, and interstitial cell damage resulting in impaired renal functioning. Our application is focused on self-lubricating and self-healing calcium phosphate (CaP) reinforced Ti- or CoCrMo-alloys to minimize bio-tribocorrosion in applications such as trunnions in modular taper interlocks in THAs. CoCrMo-CaP composite will be designed to minimize Co and Cr ion release compared to pure CoCrMo alloy; while Ti alloy- CaP composites will be designed to completely eliminate the release of Co and Cr ions due to corrosion or wear degradation. The objective of this proposed research is to test our central hypothesis that CaP based solid lubricants in Ti or CoCrMo alloys will form an in situ film at the contact surface to minimize bio- tribo-corrosion and reduce metal ion release. The rationale is that once we understand the mechanisms of tribofilm formation and its influence on bio-tribo-corrosion, we can design implants with reduced metal ion release possibility in vivo. Our preliminary data show in situ tribofilm formation with CaP reinforcement in Ti6Al4V or CoCrMo alloys during in vitro bio-tribo- corrosion studies. Presence of tribofilm lowered wear induced damage and minimized metal ion release in vitro. We have three Specific Aims for the proposed program – (1) to understand tribocorrosion mechanism and tribofilm formation in CaP reinforced Ti-alloy matrix composites, and measure their in vitro biological response; (2) to understand tribocorrosion mechanism and tribofilm formation in CaP reinforced CoCrMo composites, and measure their in vitro biological response, and (3) to measure in vivo biological properties of CaP added Ti or CoCrMo alloys.

在承重植入物中，全髋关节置换术（THA）可能是临床应用最广泛的。 成功干预。 CoCrMo 合金是一种首选耐磨材料，通常用于 用于 THA 的股骨头。 THAs 的体内寿命通常会因碎片的产生而缩短，并且 Co 和 Cr 金属离子从模块化连接处释放。耳轴锥度腐蚀的管理 CoCrMo 刀头和 Ti6Al4V 刀杆的加工如今仍然是一个严峻的挑战。锥度腐蚀 发生的主要原因是机械辅助缝隙腐蚀 (MACC) 以及微动磨损 和电偶腐蚀，并导致局部组织不良反应（ALTR），这是一种免疫- 由于 Co 和 Cr 离子升高而介导的生物反应。 ALTR 影响深远 骨，导致种植体失败，从而可能导致早期修复手术。 Co 和 Cr 离子可以 还会引起其他症状，例如耳聋、失明和间质细胞损伤，从而导致 肾功能受损。我们的应用专注于自润滑和自修复 磷酸钙 (CaP) 增强 Ti 或 CoCrMo 合金，可最大限度地减少生物摩擦腐蚀 应用，例如 THA 中模块化锥形联锁中的耳轴。 CoCrMo-CaP复合材料将 与纯 CoCrMo 合金相比，旨在最大限度地减少 Co 和 Cr 离子的释放；而钛合金- CaP 复合材料的设计旨在完全消除由于以下原因而释放的 Co 和 Cr 离子： 腐蚀或磨损退化。 这项研究的目的是检验我们的中心假设，即基于 CaP 的固体 Ti 或 CoCrMo 合金中的润滑剂将在接触表面形成原位薄膜，以最大限度地减少生物效应 摩擦腐蚀并减少金属离子释放。理由是，一旦我们了解了 摩擦膜形成的机制及其对生物摩擦腐蚀的影响，我们可以设计 体内金属离子释放可能性降低的植入物。我们的初步数据显示 体外生物摩擦过程中 Ti6Al4V 或 CoCrMo 合金中 CaP 强化的摩擦膜形成 腐蚀研究。摩擦膜的存在降低了磨损引起的损坏并最大限度地减少了金属离子 体外释放。我们对拟议计划有三个具体目标 – (1) 理解 CaP增强钛合金基复合材料中的摩擦腐蚀机理和摩擦膜形成， 并测量它们的体外生物反应； (2)了解摩擦腐蚀机理 CaP 增强 CoCrMo 复合材料中摩擦膜的形成，并测量其体外生物学 (3)测量CaP添加Ti或CoCrMo合金的体内生物学特性。