The effect of Amyloid-(beta) and Tau proteins on the hippocampal neural(beta) and Tau proteins on the hippocampal neural networks and animal's ability

淀粉样蛋白(β)和Tau蛋白对海马神经网络(β)和Tau蛋白对海马神经网络和动物能力的影响

• 批准号: 2429777
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2429777
• 关键词: effect; Amyloid; beta; Tau; proteins

Animals navigate through the environment by using a spatial map created in the hippocampus, the area of the brain crucially important for learning and declarative memory. Although we have already discovered the key components of this map (grid, place, border and head-direction cells)1, the exact causality between their activity and their role in spatial memory remains elusive. This is especially important, because Alzheimer's disease (AD) begins to develop in the hippocampus prior to the onset of clinical signs and subsequently spreads to the neocortex.2 Therefore, the development of the disease could in principle be understood by carefully monitoring the animal's ability to navigate from early to later stages of AD. In order to do this, we will design a fully-automated system for behavioral phenotyping of healthy and AD-model rodents. These insights will not only allow us to design efficient early diagnosis methods, but also elucidate a more precise functional role of hippocampal spatial cells.

动物通过使用海马体中创建的空间地图在环境中导航，海马体是大脑中对学习和陈述性记忆至关重要的区域。虽然我们已经发现了这个地图的关键组成部分（网格，位置，边界和头部方向细胞），但它们的活动与它们在空间记忆中的作用之间的确切因果关系仍然难以捉摸。这一点尤其重要，因为阿尔茨海默病（AD）在临床症状出现之前就开始在海马体中发展，随后扩散到新皮质。2因此，原则上可以通过仔细监测动物从AD早期到晚期的导航能力来了解疾病的发展。为了做到这一点，我们将设计一个全自动系统，用于健康和AD模型啮齿动物的行为表型分析。这些见解不仅使我们能够设计有效的早期诊断方法，而且还阐明了海马空间细胞更精确的功能作用。