HEI Core Center for Hearing Research

简介（由申请人提供）：HEI听力研究核心中心旨在支持和促进研究，促进合作，并在以下四个领域制定新的研究方向：1)人类受试者招募，2)工程学，3)成像/形态学，4)动物研究。核心A：集中的人类研究对象数据库将为HEI的研究人员提供一个集中的人类受试者数据库。核心的目标是为招募人类受试者参与高等教育学院的研究提供支持，并通过更快、更容易地选择合适的受试者来提高研究工作的效率和生产力。核心还旨在促进研究人员之间的合作，他们将利用这一核心提供的机会。核心B：工程将开发和维护实时数字信号处理（DSP）的硬件和软件专业知识。核心还将与特定项目的工程师进行交互，以将他们的自定义输入和输出需求接口到DSP核心模块。此外，Core将为用于行为听力以及ABR和OAE测量系统的标准音频设备提供基本设备配置和校准服务。核心C：成像和形态学旨在为HEI科学家提供最先进的形态学和显微镜服务和培训。这些服务包括检查和维护所有成像设备、图像存储和提供培训。增加一名组织学技术人员将有助于实现这一目标。核心将对所有成像设备进行检查和维护。核心还将鼓励协作和传播有关成像领域进展的信息。核心D：突变动物模型旨在提供卓越的畜牧业，包括小鼠和其他物种的健康监测，育种和记录保存。其工作人员还将负责DNA分离和PCR基因分型，以及引物设计和排序。增加一名畜牧业和一名基因分型技术人员将使我们能够有效地履行这些职能。这个核心的另一个目标是增加互动和合作的机会。

DESCRIPTION (provided by applicant): The HEI Core Center for Hearing Research aims to support and facilitate research, foster collaborations and set new research directions in the following four areas: 1) human subject recruitment, 2) engineering, 3) imaging/morphology, and 4) animal studies. Core A: Centralized Human Research Subject Database will provide a centralized database of human subjects for investigators at HEI. The goals of the Core are to provide support in recruiting human subjects for participation in research studies at HEI and to improve efficiency and productivity of the research endeavors by making it faster and easier to select appropriate subjects. The Core also aims to foster collaborations among investigators who will take advantage of the opportunities provided by this core. Core B: Engineering will develop and maintain hardware and software expertise on real-time digital signal processing (DSP). The Core will also will interact with project-specific engineers to interface their custom input and output needs to the DSP core modules. In addition, the Core will provide basic equipment configuration and calibration services for standard audio equipment used for behavioral hearing as well as ABR and OAE measurement systems. Core C: Imaging and Morphology aims to provide state-of-the-art morphology and microscopy services and training to HEI scientists. Such services include inspection and maintenance of all imaging equipment, image storage, and providing training. The addition of a histology technician will help towards the achievement of this objective. The Core will perform inspection and maintenance of all imaging equipment. The Core will also encourage collaboration and dissemination of information about advances in the field of imaging. Core D: Mutant Animal Models aims to provide excellence in animal husbandry, including health monitoring, breeding and record keeping for mice and other species. Its personnel will also be responsible for DNA isolation and PCR genotyping, as well as for primer design and ordering. The addition of a husbandry and a genotyping technician will allow us to perform these functions efficiently. Another aim of this Core is to increase the opportunity for interactions and collaborations.