Older Americans Independence Center

描述（由申请人提供）：本提案旨在在约翰霍普金斯医疗机构建立一个美国老年人独立中心。该中心的重点是通过制定干预措施来预防或改善虚弱以及虚弱老年人面临的许多严重不良后果，促进虚弱老年人的独立性。为了实现这一目标，该机构多个部门和项目的高级和初级研究人员组成的多学科小组提议通过该OAIC实施1.领导小组，将刺激，领导和维持一个大学范围内的跨学科研究计划调查脆弱，其病因和治疗的机会; 2。基础设施和方法的发展至关重要，以创造下一代的研究脆弱的老年人; 3。支持致力于研究事业的优秀青年教师的职业发展，这将导致虚弱的治疗和预防;和4。培养和支持试点研究，为长期由政府发起和资助的脆弱性研究奠定基础。OAIC将提供至关重要的支持，将该机构现有的大量力量组织成一个统一和有力的努力，旨在制定针对脆弱的干预措施。它的目的是确保基础和临床/人口为基础的研究之间的多学科翻译，并两者到脆弱的治疗方法的发展。这种有组织的基础设施和科学领导可以作为我们自己的机构和其他机构在衰老脆弱研究领域的研究人员的建议和合作的来源。OAIC将由约翰霍普金斯老龄化与健康中心在行政上领导并设在该中心内，所有致力于老龄化研究的机构项目都将发挥强有力的领导作用并参与其中;它还将吸纳以前未参与过脆弱性研究但在本提案的规划过程中致力于这项工作的领导人和研究人员。该办公室具有强有力的机构承诺，其基础是医疗机构的优先事项，即统一和加强老龄化研究，并突出其对整个机构的重要性。总体而言，它旨在引领新的研究深度和强度，以改善结果并促进体弱老年人的独立性。

DESCRIPTION (provided by applicant): This proposal seeks to establish an Older Americans Independence Center at the Johns Hopkins Medical Institutions. The focus of this center is to promote independence for frail older adults through the development of interventions to prevent or ameliorate frailty and the many serious, adverse outcomes that frail older adults are at risk for. To accomplish this, a multidisciplinary group of senior and junior investigators, in multiple Departments and Programs at this institution, propose to implement, through this OAIC, 1. the leadership group that will stimulate, lead and sustain a University-wide interdisciplinary research program investigating frailty, its etiology and opportunities for treatment; 2. the infrastructure and methodologic development essential to creating the next generations of research on frailty in older adults; 3. to support the career development of outstanding junior faculty committed to research careers that will lead to treatments for frailty and its prevention; and 4. to cultivate and support pilot studies that will provide the basis for investigator-initiated and funded research on frailty over the long run. The OAIC would provide the support critical to organizing the substantial strengths already at this institution into a unified and potent effort directed at developing interventions for frailty. It is designed to ensure multidisciplinary translation between basic and clinical/population-based research, and of both into development of treatments for frailty. This organized infrastructure and scientific leadership can serve as a source of advice and collaborations to investigators at our own institution and at other institutions in the area of research on frailty in aging. The OAIC will be administratively led by, and housed in, the Johns Hopkins Center on Aging and Health, with strong leadership and participation by all of the institutional programs committed to aging research; it will also incorporate leaders and investigators not previously involved in research on frailty but who have made a commitment to this work through the planning process for this proposal. This OAIC has strong institutional commitment, based on the priority at the Medical Institutions for the unification and strengthening of aging research and spotlighting its importance for the entire institution. Overall, it is designed to spearhead a new depth and intensity of research to improve outcomes and promote independence for frail, older adults.