WHAS II

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。随着美国越来越关注如何减轻与衰老相关的残疾负担，我们一直在进行一项研究，以确定有残疾风险的老年妇女及其残疾的原因。本研究是在OPD-GCRC的空间和人员支持下进行的，并通过由研究者发起的国家老龄化研究所题为“老年妇女身体残疾的危险因素”的RO1进行。该研究被称为妇女健康与老龄化研究II (WHAS II)，是一项前瞻性观察性研究，对436名基线年龄为70-79岁的妇女进行队列研究，以确定早期功能衰退的特征，称为“临床前残疾”，临床前残疾的危险因素和潜在原因，以及残疾和依赖的进展，以及身体功能的早期下降是否可以预测未来的残疾。该研究于2000年6月通过R01的竞争性更新获得退款，在5年内进行了3次以上的检查。我们获得了免费延期，从2005年6月1日到2006年5月31日。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With concern increasing in the U.S. to understand how to decrease the burden of disability associated with aging, we have been conducting a study to define older women at risk of disability and the causes of disablement. This study is conducted with support of space and personnel from the OPD-GCRC and through an investigator-initiated RO1 from the National Institute on Aging entitled "Risk Factors for Physical Disability in Aging Women". The study, referred to as the Women's Health and Aging Study II (WHAS II), is a prospective, observational study of a cohort of 436 women 70-79 years of age at baseline, to determine the characteristics of early functional decline, termed "preclinical disability", the risk factors and underlying causes of preclinical disability and progression to disability and dependency and whether early decrements in physical functioning are predictive of future disability. The study was refunded in June 2000 through a competitive renewal of the R01 to conduct 3 more examinations over a 5-year period. We were granted a no cost extension which supports the study from 6/1/05 thru 5/31/06.