Development of graphene containing 3D printed scaffolds for orthopaedic applications

开发用于骨科应用的含石墨烯 3D 打印支架

• 批准号: 2430101
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2430101
• 关键词: Development; graphene; containing; 3D; printed

There is a huge unmet need for millions of people worldwide who suffer bone loss due to injury, infection, disease, or abnormal skeletal development for substitute bone that can seamlessly incorporate itself into the body.Synthetic materials that can mimic the bone architecture at the micro and macro-scale as alternative bone graft substitutes eliminate risks of donor site morbidity and infection, while being readily available. Substrate intrinsic characteristics such as chemistry, nanotopography and mechanical properties can induce adult stem cell differentiation towards specific lineages. For bone cell growth, vascularization and extracellular matrix deposition stiff 3D porous scaffolds that mimic the bone tissue microenvironment are needed, which traditional methods such as freeze-drying and salt-leaching cannot produce. 3D printing (additive manufacturing), due to a uniform deposition of material according to a computer aided design, can seamlessly control size, density and pore interconnectivity therefore produce patient tailored architectures.

全球数以百万计因受伤、感染、疾病或骨骼发育异常而遭受骨质流失的人对能够无缝融入体内的替代骨有着巨大的未满足需求。作为替代骨移植替代品，可以在微观和宏观尺度上模仿骨骼结构的合成材料可以消除供体部位发病和感染的风险，同时易于获得。基质的内在特性，如化学、纳米形貌和机械特性，可以诱导成体干细胞向特定谱系分化。对于骨细胞生长、血管化和细胞外基质沉积，需要模拟骨组织微环境的刚性 3D 多孔支架，这是传统方法（如冷冻干燥和盐浸）无法生产的。 3D 打印（增材制造）由于根据计算机辅助设计均匀沉积材料，可以无缝控制尺寸、密度和孔隙互连性，从而产生患者定制的结构。