ZnO/Graphene复合量子点的表面特性调控、吸附作用及抗菌性能增强机制

纳米材料与细菌之间的相互作用是决定其抗菌效果的重要环节。本项目针对如何提高纳米材料与细菌之间的相互作用这一问题，拟以小尺寸ZnO/Graphene复合量子点为研究对象，利用静电吸附原理，采用各种不同类型的阳离子型有机聚合物对ZnO/Graphene复合量子点进行表面修饰，增大复合量子点表面可与大肠杆菌相互作用的吸附活性位点数目，有效地缩短活性氧物质的扩散路径，最终实现纳米材料抗菌性能的显著提升。阐明合成过程和环境参数控制与复合量子点组成、表面特性等之间的内在联系。系统地研究有机聚合物表面基团种类、分子量、链长、包覆量等因素对复合量子点与大肠杆菌之间吸附作用，以及活性氧物质产生、扩散作用的影响规律，揭示ZnO/Graphene复合量子点与有机聚合物之间的协同抗菌作用及抗菌性能增强机制，为新型高效纳米复合抗菌剂的设计与合成提供新思路。

The interaction between nanomaterials and bacteria plays an important role in determining the antibacterial effect of nanomaterials. In this project, smaller size ZnO/graphene quantum dot conjugates were chosen as the research subjects to solve this problem. They were modified with various kinds of cationic organic polymers, which increased the number of adsorptive active sites that could interact with Escherichia coli on the surface of quantum dot conjugates, and effectively shortened the diffusion path of reactive oxygen species (ROS). Finally, the antimicrobial properties of nanomaterials could be improved significantly. The relationship among the synthesis process, the environmental parameters, the composition and surface properties of quantum dots were explored. The effects of groups on the surface of organic polymers, molecular weight, chain length and coating amount on the adsorption between the quantum dot conjugates and Escherichia coli, as well as the production and diffusion of reactive oxygen species, were systematically studied. The synergistic antibacterial action between ZnO/Graphene quantum dot conjugates and organic polymers, as well as the mechanism of enhanced antibacterial activities were revealed. This research could provide new ideas for the design and synthesis of high efficient nanocomposite antimicrobial agents.