Core Grant for Vision Research

本P30提案要求提供部分资金，以支持塔夫茨视力研究中心(TCVR)内三个核心资源模块的运作。课程包括：1)形态学，2)单抗和组织资源，3)计算生物学。与TCVR相关的另一个模块-转基因小鼠-由该研究所资助。TCVR目前包括波士顿塔夫茨健康科学园区的27名教职员工的研究活动，其中包括17名由NEI资助的首席调查人员，他们总共持有22项NEI补助金。这些研究人员来自塔夫茨大学六个不同的系和两个不同的学院，他们的研究活动已经有效地整合到TCVR的保护伞下。波士顿校区城市校园环境中的研究实验室非常接近，临床和基础科学系的研究人员交叉任命，以及他们在研究生课程中的共同服务，这都促进了这一点。这些模块被安置在三个系的研究空间中：眼科、解剖学和细胞生物学以及神经科学系。该小组代表的主要科学学科包括生物化学、生物工程、生物统计学、细胞生物学、发育生物学、流行病学、遗传学、免疫学、分子生物学、神经生物学、营养学、药理学和生理学。这些科学家研究的眼睛生物学和疾病的一般类别包括角膜生理和疾病、白内障、眼睛的发育生物学、青光眼、视网膜疾病、眼睛的营养和衰老，以及眼科遗传学。

This P30 proposal is a request for for partial funding to support the operation of three core resource modules within the Tufts Center for Vision Research (TCVR). The modules are: 1) Morphology, 2) Monoclonal Antibodies and Tissue Resources, and 3) Computational Biology. An additional module associated with the TCVR, Transgenic Mice, is funded by the Institution. The TCVR currently comprises the research activities of 27 faculty members on the Tufts Health Sciences campus in Boston, including 17 NEI-funded Principal Investigators who hold a total of 22 NEI grants. Research activities of these investigators, who come from six different departments and two different schools of Tufts University, have been effectively integrated under the TCVR umbrella. This is facilitated by the close proximity of investigator labs within the urban campus environment of the Boston campus, by the cross-appointment of investigators to both clinical and basic science departments, and by their common service in the graduate programs. The modules are housed in research space located within three departments: Ophthalmology, Anatomy and Cellular Biology, and Neuroscience. Major scientific disciplines represented in the group include biochemistry, bioengineering, biostatistics, cell biology, developmental biology, epidemiology, genetics, immunology, molecular biology, neurobiology, nutrition, pharmacology, and physiology. The general categories of eye biology and disease addressed by these scientists include corneal physiology and disease, cataract, developmental biology of the eye, glaucoma, retinal disease, nutrition and aging in the eye, and ophthalmic genetics.