Evaluation of Novel Pyrrolo/Iminoquinone Antimalarial Compounds

新型吡咯/亚氨基醌抗疟化合物的评价

• 批准号: nhmrc : 1024314
• 负责人: A/Pr Mark Coster
• 金额: $ 40.96万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/evaluation-novel-pyrroloiminoquinone-antimalarial-compounds/110337
• 关键词: Evaluation; Novel; Pyrrolo; Iminoquinone; Antimalarial

The development of new antimalarial drugs is an unmet global health priority. In this project we will investigate novel compounds that have been found to display promising in vitro antimalarial activity. We will modify these compounds to make them more drug-like, and assess their efficacy in vivo using malaria animal models. These studies have the potential to identify compounds that may result in a new therapy for malaria, the worlds' most significant tropical infectious disease.

开发新的抗疟药物是一个尚未得到满足的全球卫生优先事项。在这个项目中，我们将研究新的化合物，已被发现显示有前途的体外抗疟活性。我们将修改这些化合物，使它们更像药物，并使用疟疾动物模型评估它们的体内功效。这些研究有可能确定可能导致疟疾新疗法的化合物，疟疾是世界上最重要的热带传染病。