Concordance Rates of Mobiluncus Among Sexual Partners

描述（由申请人提供）：细菌性阴道炎（BV）是世界范围内最普遍的阴道炎形式，与早产和性病/艾滋病感染等并发症有关。细菌性阴道炎的病因尚不清楚，尽管它的流行病学反映了一种性传播疾病。大多数与细菌性阴道炎相关的微生物通过培养技术在健康阴道中少量检测到，但Mobiluncus spp似乎与细菌性阴道炎密切相关。然而，这种生物是一种高度挑剔的厌氧菌，培养可能低估了阴道样本中的真实患病率。我们建议使用聚合酶链技术（PCR）来检测Mobiluncus物种在性伴侣中的一致性率。我们的假设是curtisii Mobiluncus在BV的发病机制中很重要，并且性伴侣之间的高一致性率将被发现表明性传播。

DESCRIPTION (provided by applicant): Bacterial vaginosis (BV) is the most prevalent form of vaginitis worldwide and has been linked to complications such as preterm birth and STD/HIV acquisition. The etiology of BV remains unknown although its epidemiology mirrors that of a sexually transmitted disease. Most of the microorganisms associated with BV are detected by culture techniques in the healthy vagina in small numbers with the exception of Mobiluncus spp. which seems to be strongly associated with BV. However, this organism is a highly fastidious anaerobe and culture may underestimate the true prevalence in vaginal samples. We propose to use polymerase chain techniques (PCR) to examine the concordance rates of Mobiluncus species among sexual partners. Our hypothesis is that Mobiluncus curtisii is important in the pathogenesis of BV and high concordance rates among sexual partners will be found suggesting sexual transmission.