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A nanostructured coating platform technology for protection and functionalisation of magnesium-based implants

用于镁基植入物保护和功能化的纳米结构涂层平台技术

基本信息

批准号：
2433264
负责人：
金额：
--
依托单位：
University of Nottingham
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2433264
关键词：
nanostructured coating platform technology protection

项目摘要

Degradable metals have significant potential for enhancing performance of medical implants in a number of clinical fields including cardiovascular and orthopaedics. Magnesium has attracted increasing attention as a biomaterial for degradable medical implants in recent years. The principal limitation to realising this potential is the uncontrolled, rapid, corrosion of magnesium at physiological pH in the high chloride environment of the physiological system. Attempts to control degradation have used alloying Mg and coatings/surface treatments. Success with these have been modest at best. This proposal aims to demonstrate the potential for PVD coating technology to provide tailored degradation of magnesium-based implantable medical device. The technology comprises a novel innovative multiphase nanostructured coating to control the durability of magnesium implantable medical devices. The multilayer coatings will contain a novel amorphous filling layer that fills defects in the degradable layer to prevent crevice corrosion accelerating the control layer. This is an approach that is used for dielectric materials and part of this research will be to establish a biocompatible version. The development of these coatings will be underpinned by high impact fundamental science to understand the relationship between composition, structure and mechanism of degradation of the nanostructured coatings.

可降解金属在许多临床领域（包括心血管和骨科）中具有显著的提高医疗植入物性能的潜力。镁作为可降解医用植入物的生物材料，近年来受到越来越多的关注。实现这一潜力的主要限制是在生理系统的高氯化物环境中的生理pH下镁的不受控制的快速腐蚀。控制降解的尝试已经使用合金化Mg和涂层/表面处理。这方面的成功充其量也是有限的。该提案旨在证明PVD涂层技术为镁基植入式医疗器械提供定制降解的潜力。该技术包括一种新型的创新多相纳米结构涂层，用于控制镁可植入医疗器械的耐久性。多层涂层将包含一种新型的无定形填充层，该填充层填充可降解层中的缺陷，以防止裂缝腐蚀加速控制层。这是一种用于介电材料的方法，本研究的一部分将是建立一种生物相容性版本。这些涂层的发展将受到高影响基础科学的支持，以了解纳米结构涂层的组成，结构和降解机制之间的关系。