Soy phytoestrogen supplementation and menopause

大豆植物雌激素补充和更年期

• 批准号: 6760727
• 负责人: CYNTHIA K SITES
• 金额: $ 13.29万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6760727
• 关键词: adipose tissue; body composition; clinical research; clinical trials; computed axial tomography; dietary supplements; female; glucose clamp technique; glucose metabolism; human subject; insulin; nutrition related tag; obesity; pancreatic islet function; phytoestrogens; postmenopause; soybeans; women' s health

DESCRIPTION (provided by applicant): Dr. Cynthia K. Sites is an Associate Professor of Obstetrics and Gynecology and Director of the Fellowship Program in Reproductive Endocrinology and Infertility at the University of Vermont College of Medicine. Dr. Sites' major research goal is to understand and develop new therapeutic strategies to alleviate increased cardiovascular disease risk following menopause. This K24 Midcareer Award in Patient-Oriented Research will ensure that Dr. Sites devotes at least 40% of her effort to patient-oriented research and mentoring of clinical investigators. Although Dr. Sites has conducted several patient-oriented research projects toward this goal, this proposal describes Dr. Sites' study, "Soy Phytoestrogens and Metabolic Cardiovascular Risk." Since the publication of the Women's Health Initiative findings, postmenopausal women are discontinuing hormone replacement therapy and considering alternative strategies such as soy phytoestrogens. Our overall hypothesis is that dietary supplementation with soy phytoestrogens improves glucose metabolism by increasing glucose disposal and reducing insulin secretion, which reduce the risk of cardiovascular disease. Fellows to be mentored by Dr. Sites through this K24 award will be trained to develop hypotheses and carry out projects consistent with these goals. The Candidate has demonstrated continued commitment to mentoring and training fellows, residents, and medical students in Patient-Oriented Research, and has the full support of her department and the General Clinical Research Center for this project.

描述（由申请人提供）：Cynthia K. Sites 博士是佛蒙特大学医学院妇产科副教授兼生殖内分泌学和不孕不育研究金项目主任。 Sites 博士的主要研究目标是了解和开发新的治疗策略，以减轻更年期后增加的心血管疾病风险。 K24 面向患者的研究中职业生涯奖将确保 Sites 博士将至少 40% 的精力投入到面向患者的研究和临床研究人员的指导上。尽管 Sites 博士已为此目标开展了多个以患者为导向的研究项目，但本提案描述了 Sites 博士的研究“大豆植物雌激素和代谢性心血管风险”。自从《妇女健康倡议》研究结果发表以来，绝经后妇女正在停止激素替代疗法，并考虑采用大豆植物雌激素等替代策略。我们的总体假设是，膳食补充大豆植物雌激素可以通过增加葡萄糖处理和减少胰岛素分泌来改善葡萄糖代谢，从而降低心血管疾病的风险。通过 K24 奖项接受 Sites 博士指导的研究员将接受培训，以提出假设并开展与这些目标一致的项目。 该候选人表现出对以患者为导向的研究方面指导和培训研究员、住院医师和医学生的持续承诺，并得到了她所在部门和综合临床研究中心对该项目的全力支持。