Soy phytoestrogen supplementation and menopause

描述(由申请人提供)：辛西娅·K·赛德斯博士是佛蒙特大学医学院妇产科副教授，生殖内分泌学和不孕不育奖学金项目主任。赛斯博士的主要研究目标是了解和开发新的治疗策略，以减轻绝经后心血管疾病风险的增加。这项以患者为中心的K24职业生涯中期奖将确保Sites博士将至少40%的精力投入到以患者为中心的研究和临床研究人员的指导上。尽管SITES博士为实现这一目标进行了几个以患者为中心的研究项目，但该提案描述了SITES博士的研究--“大豆植物雌激素与新陈代谢心血管风险”。自从《妇女健康倡议》的研究结果发表以来，绝经后妇女正在停止激素替代疗法，并考虑替代策略，如大豆植物雌激素。我们的总体假设是，饮食中补充大豆植物雌激素可以通过增加葡萄糖代谢和减少胰岛素分泌来改善葡萄糖代谢，从而降低心血管疾病的风险。通过这个K24奖项，由Dr.Sites指导的研究员将接受培训，以开发假设并执行与这些目标一致的项目。这位候选人一直致力于指导和培训研究员、住院医生和医学生进行以患者为中心的研究，并得到了她所在部门和综合临床研究中心的全力支持。

DESCRIPTION (provided by applicant): Dr. Cynthia K. Sites is an Associate Professor of Obstetrics and Gynecology and Director of the Fellowship Program in Reproductive Endocrinology and Infertility at the University of Vermont College of Medicine. Dr. Sites' major research goal is to understand and develop new therapeutic strategies to alleviate increased cardiovascular disease risk following menopause. This K24 Midcareer Award in Patient-Oriented Research will ensure that Dr. Sites devotes at least 40% of her effort to patient-oriented research and mentoring of clinical investigators. Although Dr. Sites has conducted several patient-oriented research projects toward this goal, this proposal describes Dr. Sites' study, "Soy Phytoestrogens and Metabolic Cardiovascular Risk." Since the publication of the Women's Health Initiative findings, postmenopausal women are discontinuing hormone replacement therapy and considering alternative strategies such as soy phytoestrogens. Our overall hypothesis is that dietary supplementation with soy phytoestrogens improves glucose metabolism by increasing glucose disposal and reducing insulin secretion, which reduce the risk of cardiovascular disease. Fellows to be mentored by Dr. Sites through this K24 award will be trained to develop hypotheses and carry out projects consistent with these goals. The Candidate has demonstrated continued commitment to mentoring and training fellows, residents, and medical students in Patient-Oriented Research, and has the full support of her department and the General Clinical Research Center for this project.